Contents
September 2018
Vol 3, Issue 27
Vol 3, Issue 27
Editorial
- A FRESH approach: Combining basic science and social good
A program to study HIV infection is empowering African women.
Research Articles
- Molecular diversification of regulatory T cells in nonlymphoid tissues
Different tissue microenvironments differentially refine Treg cell transcriptional regulatory modules already primed in lymphoid organs.
- Inception of early-life allergen–induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells
The lymphoid cellular source of IL-13 driving AHR is age-dependent.
- Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis
T cell responses to subunit vaccination require both IL-27 and IL-15 to support an aerobic glycolysis–independent metabolic program.
Review
- Recording the wild lives of immune cells
This Review covers the toolbox available to researchers to study immune cell behavior by using intravital imaging.
Editors' Choice
- One, two, three—how many cells for me?
An alternate strategy is described for enumerating peripheral immune cells in health and disease by epigenetic quantitative PCR.
- Colitis interruptus: LAGing gut inflammation
Regulatory T cells indirectly suppress ILC3-driven colitis by suppressing gut-resident macrophages in a LAG-3–dependent manner.
About The Cover
ONLINE COVER Lights, camera, action. Featured on the cover is a hand-drawn sketch of a microscopy room used for intravital imaging by authors Mikael Pittet and Sean Arlauckas. In this Review, Pittet et al. examine the fundamentals of using intravital microscopic imaging to study single cells and highlight how this technology has allowed us to directly visualize the movement and activities of immune cells in various tissues. They also provide a comprehensive overview of mouse reporter lines that are currently available to monitor immune cell dynamics using intravital imaging. [CREDIT: MIKAEL PITTET & SEAN ARLAUCKAS]