Contents
December 2018
Vol 3, Issue 30
Vol 3, Issue 30
Focus
- Good things come in threes
Ectopic expression of PU.1, IRF8, and BATF3 reprograms mouse and human fibroblasts into dendritic cells. See related Research Article by Rosa et al.
Research Article
- Direct reprogramming of fibroblasts into antigen-presenting dendritic cells
Ectopic expression of transcription factors PU.1, IRF8, and BATF3 reprograms fibroblasts to dendritic cells.
Review
- Neutrophils: New insights and open questions
Neutrophils patrol the bloodstream and tissues to kill microbes and guide subsequent innate and adaptive immune responses.
Editors' Choice
- The depth of mutational agony and the exuberance of tumoral T cell ecstasy predict checkpoint salvation
Genomic biomarkers will help to elucidate which cancer patients will benefit from PD-1 blockade immunotherapy.
About The Cover
ONLINE COVER "Induced" Dendritic Cells. In this issue, Rosa et al. report that ectopic expression of three transcription factors—PU.1, IRF8, and BATF3—is sufficient to reprogram mouse and human fibroblasts into "induced" dendritic cells. Featured on the cover is a colored scanning electron micrograph showing an "induced" dendritic cell with prominent cytoplasmic protrusions. [CREDIT: JONAS AHLSTEDT & SEBASTIAN WASSERSTROM/LUND UNIVERSITY BIOIMAGING CENTER]