Contents
February 2019
Vol 4, Issue 32
Vol 4, Issue 32
Focus
- Myeloid cells in the central nervous system: So similar, yet so different
Dissection of the heterogeneity of CNS myeloid cells reveals functionally distinct subsets that govern encephalitogenic T cells. See related Research Articles by Jordão et al.
- A perfect storm: Genetics and anticommensal antibodies shore up type 1 diabetes
HLA haplotypes in conjunction with serum anticommensal antibody responses are predictive of type 1 diabetes progression. See related Research Article by Paun et al.
Research Articles
- Optimal therapeutic activity of monoclonal antibodies against chikungunya virus requires Fc-FcγR interaction on monocytes
Anti–chikungunya virus antibodies require FcγR engagement but not complement activation for protection and viral clearance.
- The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network
Quantitative activity through the TCR-proximal protein network specifies thymic positive versus negative selection.
- Diet modulates colonic T cell responses by regulating the expression of a Bacteroides thetaiotaomicron antigen
Diet alters symbiont-specific immune responses via regulation of the expression of an outer membrane vesicle antigen.
- Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children
Immune responses to gut bacteria display HLA-dependent associations with progression to type 1 diabetes.
Research Resource
- Multifactorial heterogeneity of virus-specific T cells and association with the progression of human chronic hepatitis B infection
Comprehensive epitope mapping and high-dimensional analyses uncover complex relationships of virus-specific memory T cells in CHB.
Editors' Choice
- A ten-acious cytokine for a tenacious infection
T follicular helper cells produce interleukin-10 during chronic viral infections to support the humoral response.
- Belly-born B cells bathe the brain
IgA-expressing antibody secreting cells that are formed in the gut travel to the brain to diminish inflammation during multiple sclerosis exacerbations.
About The Cover
ONLINE COVER Monitoring Anticommensal Antibodies. This month's cover illustration is a scanning electron micrograph of human feces in which individual commensal bacteria have been colorized to highlight the range of different species present. Paun et al. report development of an assay platform to detect serum anticommensal antibodies that correlate with development of autoimmune and inflammatory diseases. This assay enabled identification of changes in the titer of anticommensal antibodies that exhibit an HLA-dependent association with progression to type 1 diabetes in prediabetic children with islet autoantibodies. [CREDIT: STEVE GSCHMEISSNER/Science Source]