Contents
May 2018
Vol 3, Issue 23
Vol 3, Issue 23
Focus
- Antibodies that lIgAte our intestinal microbes
Perturbations in gut microbiota of IgA-deficient humans provide insight into how secretory IgA shapes microbiota composition (see the related research article by Fadlallah et al.).
Research Articles
- Tumor immune evasion arises through loss of TNF sensitivity
Whole-genome CRISPR screens identify resistance to TNF-mediated killing by T and NK cells as a tumor immune evasion mechanism.
- Mitochondrial cyclophilin D regulates T cell metabolic responses and disease tolerance to tuberculosis
The regulation of a T cell metabolic program is a critical component of host tolerance to tuberculosis.
- MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1
Expression of microRNA-146a limits IFN-γ production in IL-17–producing γδ T cells.
Editors' Choice
- To EBV or not to EBV: Rational vaccine design for a common infection
A human antibody that prevents EBV infection is identified by studying memory B cells that recognize core EBV fusion proteins.
- Say it isn’t pso: IL-25 drives skin inflammation
IL-25 from keratinocytes mediates skin inflammation in psoriasis.
About The Cover
ONLINE COVER Which Path Gets the Nod? Lymphocyte differentiation involves cells committing to follow one of several diverging pathways. Schmolka et al. show that the capacity of IL-17–producing γδ T cells to also secrete IFN-γ is held in check by expression of the miR-146a microRNA. miR-146a targets mRNA encoding NOD1, a newly appreciated driver of IFN-γ production. [CREDIT: ISTOCK.COM/FLOCU]