PerspectiveIMMUNOLOGY

The discontinuity theory of immunity

Science Immunology  14 Jul 2016:
Vol. 1, Issue 1, pp. aag0479
DOI: 10.1126/sciimmunol.aag0479

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Abstract

Similar to many other biological systems, the immune system can be seen as a change-detection system. According to the discontinuity theory of immunity, the immune system responds to sudden changes in antigenic stimulation and is rendered tolerant by slow or continuous stimulation. This basic principle, which is supported by recent data on immune checkpoints in viral infections, cancers, and allergies, can be seen as a unifying framework for diverse immune responses.

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