Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor

See allHide authors and affiliations

Science Immunology  26 Aug 2016:
Vol. 1, Issue 2, pp. eaaf7471
DOI: 10.1126/sciimmunol.aaf7471

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

PreCheck for intestinal immunity

Immune cells act as TSA screeners in the intestine—tolerating commensal microbes and food antigens but remaining vigilant against attack. However, it has remained unclear how T cell precursors differentiate into the different cell types required to perform this balancing act. Now, Bilate et al. report that the T cell receptor (TCR) itself does not limit T cell fate to a single identity. The authors found that cells expressing a single TCR derived from a peripheral regulatory T cell (Treg) developed into either Tregs or CD4+CD8αα+ intraepithelial lymphocytes (CD4IELs) in the gut. This differentiation depended on cues from both the microbiota and the surrounding environment.