Research ArticleASTHMA

Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation

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Science Immunology  16 Sep 2016:
Vol. 1, Issue 3, pp. eaaf9154
DOI: 10.1126/sciimmunol.aaf9154

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Breathing down asthma’s neck

Worldwide increases in the prevalence of chronic inflammatory diseases such as asthma highlight the need for new targeted therapies. CD4+ T cells that express the activation marker CD69 contribute to the pathogenesis of some types of asthma, but the exact role of CD69 remains unclear. Hayashizaki et al. reported that myosin light chain (Myl) 9 and Myl12 are functional ligands for CD69. Myl9/12 expression was increased in inflamed mouse airways and in patients with eosinophilic chronic rhinosinusitis. These data suggest that CD69-Myl9/12 interaction is involved in recruiting activated cells to inflamed tissues. Indeed, blocking CD69-Myl9/12 interaction in two different mouse models decreased allergic airway inflammation, suggesting that targeting CD69-Myl9/12 interaction could treat chronic inflammatory diseases.