Research ArticleTOLERANCE

Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance

See allHide authors and affiliations

Science Immunology  22 Sep 2016:
Vol. 1, Issue 3, pp. eaai7732
DOI: 10.1126/sciimmunol.aai7732

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Microbes teach tolerance in the gut

The trillions of microbes inhabiting our gut can greatly affect how we respond to infection, but scientists do not fully understand the molecular mechanisms shaping how different microbes interact with the host. Rangan et al. found that both worms and mice harboring Enterococcus faecium can better tolerate Salmonella infection. In both cases, tolerance requires E. faecium to express the enzyme secreted antigen A (SagA). SagA can also exert this probiotic effect when expressed by other bacteria. SagA protects worms by cleaving bacterial peptide fragments so that they can stimulate the tol-1 protein. In mice, Pedicord et al. found that SagA protects against Salmonella and Clostridium difficile pathogenesis in a manner dependent on antimicrobial peptides and multiple innate immune receptors.