Research ArticleINFLAMMATION

Inhibition of HDAC8 and HDAC9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to TLR ligands

See allHide authors and affiliations

Science Immunology  28 Oct 2016:
Vol. 1, Issue 4, eaah4609
DOI: 10.1126/sciimmunol.aah4609

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Microbial fatty acids get under your skin

The skin plays host to many different species of microbes, tolerating their presence without the inflammatory response that greets more dangerous pathogens. Now, Sanford et al. report that short-chain fatty acids (SCFAs) produced by skin bacterium can lead to inflammatory response from keratinocytes. SCFAs produced by Propionibacterium acnes inhibited histone deacetylase (HDAC) activity in keratinocytes, which promoted the inflammatory response to innate immune ligands. These responses are cell-specific and environmentally specific—in a mouse model, SCFA induced cytokine expression on the skin but inhibited cytokine expression subcutaneously. Thus, microbial products may regulate immune tolerance of commensals in the skin.