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Research ArticleVACCINES
Adenovirus serotype 5 vaccine vectors trigger IL-27–dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function
- Rafael A. Larocca1,
- Nicholas M. Provine1,
- Malika Aid1,
- M. Justin Iampietro1,
- Erica N. Borducchi1,
- Alexander Badamchi-Zadeh1,
- Peter Abbink1,
- David Ng’ang’a1,
- Christine A. Bricault1,
- Eryn Blass1,
- Pablo Penaloza-MacMaster1,2,
- Kathryn E. Stephenson1 and
- Dan H. Barouch1,3,*
- 1Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
- 2Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611, USA.
- 3Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
- ↵*Corresponding author. Email: dbarouch{at}bidmc.harvard.edu
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Science Immunology 04 Nov 2016:
Vol. 1, Issue 5, eaaf7643
DOI: 10.1126/sciimmunol.aaf7643
Vol. 1, Issue 5, eaaf7643
DOI: 10.1126/sciimmunol.aaf7643
Rafael A. Larocca
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Nicholas M. Provine
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Malika Aid
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
M. Justin Iampietro
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Erica N. Borducchi
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Alexander Badamchi-Zadeh
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Peter Abbink
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
David Ng’ang’a
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Christine A. Bricault
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Eryn Blass
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Pablo Penaloza-MacMaster
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611, USA.
Kathryn E. Stephenson
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Dan H. Barouch
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
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