Adenovirus serotype 5 vaccine vectors trigger IL-27–dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function

Rafael A. Larocca; Nicholas M. Provine; Malika Aid; M. Justin Iampietro; Erica N. Borducchi; Alexander Badamchi-Zadeh; Peter Abbink; David Ng’ang’a; Christine A. Bricault; Eryn Blass; Pablo Penaloza-MacMaster; Kathryn E. Stephenson; Dan H. Barouch

doi:10.1126/sciimmunol.aaf7643

Research ArticleVACCINES

Adenovirus serotype 5 vaccine vectors trigger IL-27–dependent inhibitory CD4⁺ T cell responses that impair CD8⁺ T cell function

Rafael A. Larocca¹,
Nicholas M. Provine¹,
Malika Aid¹,
M. Justin Iampietro¹,
Erica N. Borducchi¹,
Alexander Badamchi-Zadeh¹,
Peter Abbink¹,
David Ng’ang’a¹,
Christine A. Bricault¹,
Eryn Blass¹,
Pablo Penaloza-MacMaster¹,²,
Kathryn E. Stephenson¹ and
Dan H. Barouch¹,³,*

¹Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
²Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611, USA.
³Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

↵*Corresponding author. Email: dbarouch{at}bidmc.harvard.edu

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Science Immunology 04 Nov 2016:
Vol. 1, Issue 5, eaaf7643
DOI: 10.1126/sciimmunol.aaf7643

Rafael A. Larocca

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Nicholas M. Provine

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Malika Aid

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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M. Justin Iampietro

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Erica N. Borducchi

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Alexander Badamchi-Zadeh

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Peter Abbink

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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David Ng’ang’a

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Christine A. Bricault

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Eryn Blass

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Pablo Penaloza-MacMaster

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611, USA.

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Kathryn E. Stephenson

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Dan H. Barouch

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

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For correspondence: dbarouch@bidmc.harvard.edu

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Adenovirus serotype 5 vaccine vectors trigger IL-27–dependent inhibitory CD4⁺ T cell responses that impair CD8⁺ T cell function

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