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IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes

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Science Immunology  11 Nov 2016:
Vol. 1, Issue 5, eaaf8612
DOI: 10.1126/sciimmunol.aaf8612

Article Information

vol. 1 no. 5

Published By: 
  • Received April 18, 2016
  • Accepted September 26, 2016

Author Information

  1. Amanda C. Poholek1,2,*,
  2. Dragana Jankovic3,
  3. Alejandro V. Villarino1,
  4. Franziska Petermann1,
  5. Angela Hettinga2,
  6. Dror S. Shouval4,5,
  7. Scott B. Snapper4,6,
  8. Susan M. Kaech7,
  9. Stephen R. Brooks8,
  10. Golnaz Vahedi1,9,
  11. Alan Sher3,
  12. Yuka Kanno1 and
  13. John J. O’Shea1,*
  1. 1Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD 20892, USA.
  2. 2Department of Pediatrics and Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
  3. 3Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  4. 4Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital, Boston, MA 02115, USA.
  5. 5Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  6. 6Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  7. 7Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  8. 8Biodata Mining and Discovery Section, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA.
  9. 9Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  1. *Corresponding author. Email: poholeka{at} (A.C.P.); john.oshea{at} (J.J.O.)


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