Research ArticleAUTOIMMUNITY

IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes

See allHide authors and affiliations

Science Immunology  11 Nov 2016:
Vol. 1, Issue 5, eaaf8612
DOI: 10.1126/sciimmunol.aaf8612

Article Information

vol. 1 no. 5

Published By: 
History: 
  • Received April 18, 2016
  • Accepted September 26, 2016

Author Information

  1. Amanda C. Poholek1,2,*,
  2. Dragana Jankovic3,
  3. Alejandro V. Villarino1,
  4. Franziska Petermann1,
  5. Angela Hettinga2,
  6. Dror S. Shouval4,5,
  7. Scott B. Snapper4,6,
  8. Susan M. Kaech7,
  9. Stephen R. Brooks8,
  10. Golnaz Vahedi1,9,
  11. Alan Sher3,
  12. Yuka Kanno1 and
  13. John J. O’Shea1,*
  1. 1Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD 20892, USA.
  2. 2Department of Pediatrics and Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
  3. 3Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  4. 4Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital, Boston, MA 02115, USA.
  5. 5Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  6. 6Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  7. 7Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  8. 8Biodata Mining and Discovery Section, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA.
  9. 9Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  1. *Corresponding author. Email: poholeka{at}pitt.edu (A.C.P.); john.oshea{at}nih.gov (J.J.O.)

AltMetrics

Article usage

AbstractFullPDF
Nov 20163563141255
Dec 20164724141
Jan 20171942722
Feb 20171131422
Mar 2017103712
Apr 201713453
May 2017124610
Jun 201711144
Jul 2017139918
Aug 201710557
Sep 201762510
Oct 20174253