The metabolic regulator mTORC1 controls terminal myeloid differentiation

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Science Immunology  26 May 2017:
Vol. 2, Issue 11, eaam6641
DOI: 10.1126/sciimmunol.aam6641

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Differentiating myeloid cells

Hematopoietic stem cells are a common progenitor of adaptive and innate immune cells. However, the precise factors that guide differentiation down these disparate pathways remain unclear in part because of difficulties working with small numbers of precursor cells. Lee et al. solve this problem for myeloid lineage cells by immortalizing murine myeloid progenitors with conditionally overexpressed Hoxb8 and labeling these cells with a Ccr2/Cx3cr1 dual reporter. They found through a small-molecule library screen and confirmatory in vivo validation that the mTORC1-S6K1-Myc pathway regulates myeloid differentiation. Disrupting this pathway in progenitors results in lack of monocytes and neutrophils. Hence, the mTORC1-S6K1-Myc pathway functions as a checkpoint in terminal myeloid differentiation.