Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function

See allHide authors and affiliations

Science Immunology  16 Jun 2017:
Vol. 2, Issue 12, eaam9304
DOI: 10.1126/sciimmunol.aam9304

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Broadening the immune spectrum

Traditionally, the immune system has been thought to have two branches—a rapid antigen-independent innate response and a more specific antigen-dependent variable response. Kawabe et al. now add to the view that the immune response covers a broader spectrum. They found that memory-phenotype CD4+ T cells are generated from naïve T cells independently of infection, aided by environmental interleukin-12 (IL-12). These cells rapidly produced IFN-γ in response to IL-12 in the absence of pathogen recognition and provided both nonspecific defense and an adaptive immune boost against the TH1 pathogen Toxoplasma gondii. These memory-phenotype CD4+ T cells provide an early innate response, forming an additional span bridging innate and adaptive immunity.