Research ArticleTHYMIC SELECTION

Human thymoproteasome variations influence CD8 T cell selection

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Science Immunology  02 Jun 2017:
Vol. 2, Issue 12, eaan5165
DOI: 10.1126/sciimmunol.aan5165

Article Information

vol. 2 no. 12

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Published By: 
History: 
  • Received April 26, 2017
  • Accepted May 24, 2017

Author Information

  1. Takeshi Nitta1,
  2. Yuta Kochi2,3,
  3. Ryunosuke Muro1,
  4. Yoshihiko Tomofuji1,
  5. Tadashi Okamura4,5,
  6. Shigeo Murata6,
  7. Harumi Suzuki7,
  8. Takayuki Sumida3,8,
  9. Kazuhiko Yamamoto2,3,9 and
  10. Hiroshi Takayanagi1,*
  1. 1Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
  2. 2Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
  3. 3Research Team for Autoimmune Diseases, Research Program for Intractable Disease of the Ministry of Health, Labour and Welfare, Tokyo, Japan.
  4. 4Department of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
  5. 5Section of Animal Models, Department of Infectious Diseases, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
  6. 6Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan.
  7. 7Department of Immunology and Pathology, Research Institute, National Center for Global Health and Medicine, Chiba 272-8516, Japan.
  8. 8Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
  9. 9Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
  1. *Corresponding author. Email: takayana{at}m.u-tokyo.ac.jp

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