Constitutive resistance to viral infection in human CD141+ dendritic cells

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Science Immunology  07 Jul 2017:
Vol. 2, Issue 13, eaai8071
DOI: 10.1126/sciimmunol.aai8071

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Divided, they conquer

Dendritic cells (DCs) play a crucial role in priming T cell–driven antiviral responses. Silvin et al. have examined the paradox of how virus-infected DCs retain the ability to drive adaptive immune responses. In response to endocytic viruses, they found CD1c+ DCs to be susceptible to infection and death, whereas CD141+ DCs were not. They report that viral resistance of CD141+ DCs was conferred by the expression of an endocytic guanosine triphosphatase, RAB15, and that transfer of antigen from infected CD1c+ DCs by CD141+ DCs allowed these virus-resistant DCs to prime T cell responses. By documenting a division of labor between DC subsets that separates antigen acquisition from antigen presentation, Silvin et al. offer a solution to this long-standing puzzle.