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Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses

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Science Immunology  25 Aug 2017:
Vol. 2, Issue 14, eaal4656
DOI: 10.1126/sciimmunol.aal4656

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For flu vaccines, age matters

Development of a broad flu vaccine has been hampered by lack of clear insight into protective mechanisms across individuals to seasonal vaccines. Avey et al. perform a systems-level analysis on multiple influenza vaccination cohorts spanning distinct geographical locations and vaccination seasons and identify prevaccination predictive transcriptional signatures of influenza vaccination responses. They validated nine genes and three gene cohorts that associated with magnitude of antibody response in an independent cohort. However, these signatures were specific to young individuals and had an inverse correlation in older individuals. These data may help to predict antibody response to influenza vaccination, as well as provide insights into the distinct mechanism governing immune responses in young and older individuals.