Lysosome signaling controls the migration of dendritic cells

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Science Immunology  27 Oct 2017:
Vol. 2, Issue 16, eaak9573
DOI: 10.1126/sciimmunol.aak9573

Lysosomal calcium powers dendritic cell migration

Activation of dendritic cells (DCs) by stimulus such as bacterial sensing promotes DC maturation. In contrast to random migratory patterns of immature DCs, mature DCs migrate in a continuous and directional manner. Here, Bretou et al. have examined the role of lysosomes in regulating migration of mature DCs. They report that release of lysosomal calcium connects DC activation with directional migration of DCs. Deletion of the lysosomal calcium channel transient receptor potential cation channel, mucolipin subfamily, member 1 (TRPML1) impaired directional DC migration and DC chemotaxis to lymph nodes. The authors propose the release of lysosomal calcium to be a key node that links stimulus sensing with DC migration.