Research ArticleFUNGAL INFECTION

Type III interferon is a critical regulator of innate antifungal immunity

See allHide authors and affiliations

Science Immunology  06 Oct 2017:
Vol. 2, Issue 16, eaan5357
DOI: 10.1126/sciimmunol.aan5357

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Type III interferons prime neutrophils

Type I interferons (IFNs) have a well-established role in antiviral immunity. Here, Espinosa et al. demonstrate that type III IFNs (IFN-λs) play an essential role in driving antifungal responses. By studying immune responses to Aspergillus fumigatus (Af) in mice lacking receptors for type I or type III IFNs, the authors found monocyte-derived type I IFNs to be key drivers of IFN-λ production. Although they could not pin down the sources of IFN-λ, they have identified neutrophils as the functional target of IFN-λs. Selective deletion of IFN-λ receptor in neutrophils caused mice to succumb to Af infection. By studying immune responses to Af, the authors have uncovered the importance of type III IFNs in antifungal immunity.