A PIP2-derived amplification loop fuels the sustained initiation of B cell activation

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Science Immunology  17 Nov 2017:
Vol. 2, Issue 17, eaan0787
DOI: 10.1126/sciimmunol.aan0787

Article Information

vol. 2 no. 17

Published By: 
  • Received March 1, 2017
  • Accepted October 4, 2017

Author Information

  1. Chenguang Xu1,
  2. Hengyi Xie1,
  3. Xingdong Guo2,
  4. Haipeng Gong3,
  5. Lei Liu4,
  6. Hai Qi5,
  7. Chenqi Xu2,6 and
  8. Wanli Liu1,*
  1. 1Ministry of Education (MOE) Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Institute for Immunology, Tsinghua University, Beijing 100084, China.
  2. 2National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  3. 3MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  4. 4Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (MOE), Department of Chemistry, Tsinghua University, Beijing 100084, China.
  5. 5Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University, Beijing 100084, China.
  6. 6School of Life Science, ShanghaiTech University, Shanghai 201210, China.
  1. *Corresponding author. Email: liulab{at}


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