Research ArticleTUMOR IMMUNOLOGY

Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity

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Science Immunology  17 Nov 2017:
Vol. 2, Issue 17, eaan4631
DOI: 10.1126/sciimmunol.aan4631

Article Information

vol. 2 no. 17

PubMed: 
Published By: 
History: 
  • Received April 17, 2017
  • Accepted October 6, 2017

Author Information

  1. Houjun Xia1,*,
  2. Wei Wang1,2,*,
  3. Joel Crespo1,3,
  4. Ilona Kryczek1,3,
  5. Wei Li1,
  6. Shuang Wei1,
  7. Zhaoqun Bian1,4,
  8. Tomasz Maj1,
  9. Mingxiao He5,
  10. Rebecca J. Liu6,
  11. Youwen He5,
  12. Ramandeep Rattan7,
  13. Adnan Munkarah7,
  14. Jun-Lin Guan8 and
  15. Weiping Zou1,3,9,10,11,
  1. 1Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
  2. 2Department of Immunology and Key Laboratory of Medical Immunology of Ministry of Public Health, Peking University Health Science Center, Beijing 100191, China.
  3. 3Graduate Program in Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
  4. 4Department of Environmental Health, Cincinnati University College of Medicine, Cincinnati, OH 45267, USA.
  5. 5Department of Immunology, School of Medicine, Duke University, Durham, NC 27710, USA.
  6. 6Department of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
  7. 7Department of Women’s Health Services, Henry Ford Health System, Detroit, MI 48202, USA.
  8. 8Department of Cancer Biology, Cincinnati University College of Medicine, Cincinnati, OH 45267, USA.
  9. 9Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
  10. 10Graduate Program in Tumor Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
  11. 11University of Michigan Comprehensive Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
  1. Corresponding author. Email: wzou{at}med.umich.edu
  1. * These authors contributed equally to this work.

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