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Teaching an old pathway new tricks: Targeting BTK to block NLRP3

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Science Immunology  03 Nov 2017:
Vol. 2, Issue 17, eaar2548
DOI: 10.1126/sciimmunol.aar2548

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Abstract

A proteomics screen identified BTK as a novel inflammasome regulator and demonstrated that blocking BTK can inhibit inflammasome activity.

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