Research ArticleDENDRITIC CELLS

Migratory CD11b+ conventional dendritic cells induce T follicular helper cell–dependent antibody responses

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Science Immunology  01 Dec 2017:
Vol. 2, Issue 18, eaam9169
DOI: 10.1126/sciimmunol.aam9169

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Priming T follicular helper cells

T follicular helper (Tfh) cells play an important role in modulating antibody production by B cells. Here, Krishnaswamy et al. have examined the ability of conventional dendritic cell (cDC) subsets to prime Tfh commitment in response to intranasal immunization in mice. They report that CD11b+ migratory type 2 cDCs (cDC2s) play an essential role in promoting commitment of activated T cells to the Tfh lineage. Using microscopy to study trafficking of cDC2s after intranasal immunization, the authors demonstrate that cDC2s have the ability to carry antigens to the T-B border of the lymph node where Tfh cell priming occurs. These findings have important implications on vaccine design and delivery.

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