Migratory CD11b+ conventional dendritic cells induce T follicular helper cell–dependent antibody responses

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Science Immunology  01 Dec 2017:
Vol. 2, Issue 18, eaam9169
DOI: 10.1126/sciimmunol.aam9169

Article Information

vol. 2 no. 18

Published By: 
  • Received February 13, 2017
  • Revision received August 11, 2017
  • Accepted October 19, 2017

Author Information

  1. Jayendra Kumar Krishnaswamy1,2,3,*,
  2. Uthaman Gowthaman1,2,*,
  3. Biyan Zhang1,2,
  4. Johan Mattsson3,
  5. Louis Szeponik4,
  6. Dong Liu1,2,
  7. Renee Wu1,5,
  8. Theresa White1,2,
  9. Samuele Calabro1,2,6,
  10. Lan Xu1,2,
  11. Magalie A. Collet7,
  12. Marina Yurieva7,
  13. Samuel Alsén4,
  14. Per Fogelstrand8,
  15. Anne Walter9,10,
  16. William R. Heath9,10,
  17. Scott N. Mueller9,10,
  18. Ulf Yrlid4,
  19. Adam Williams7,11, and
  20. Stephanie C. Eisenbarth1,2,
  1. 1Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
  2. 2Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
  3. 3Bioscience, Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, 431 50 Mölndal, Sweden.
  4. 4Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
  5. 5Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
  6. 6Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland.
  7. 7Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  8. 8Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden.
  9. 9Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria 3000, Australia.
  10. 10Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, Victoria 3000, Australia.
  11. 11Department of Genetics and Genomic Sciences, University of Connecticut Health Center, Farmington, CT 06032, USA.
  1. Corresponding author. Email: stephanie.eisenbarth{at} (S.C.E.); adam.williams{at} (A.W.)
  1. * These authors contributed equally to this work.


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