Research ArticleARTHRITIS

Complement C5a receptor is the key initiator of neutrophil adhesion igniting immune complex–induced arthritis

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Science Immunology  20 Jan 2017:
Vol. 2, Issue 7, eaaj2195
DOI: 10.1126/sciimmunol.aaj2195

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Adhering to arthritis

Autoimmune diseases, such as arthritis, are exacerbated by an inflammatory cascade that involves both immune complex deposition and neutrophil infiltration. However, how exactly immune complexes lead to neutrophil infiltration and other downstream events remains unclear. Now, Miyabe et al. use intravital imaging in joints of arthritic mice to show that complement C5a receptor (C5aR) was critical for neutrophil adhesion on joint endothelium. C5aR induced integrin-dependent neutrophil arrest and spreading, followed by extravasation mediated by leukotriene B4 receptor and crawling mediated by CCR1. CXCR2 was involved in late neutrophil recruitment and survival. These studies provide insight into the complex mechanism of neutrophil infiltration in arthritic joints.