Research ArticleHIV

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

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Science Immunology  27 Jan 2017:
Vol. 2, Issue 7, eaal2200
DOI: 10.1126/sciimmunol.aal2200

Article Information

vol. 2 no. 7

PubMed: 
Published By: 
History: 
  • Received October 14, 2016
  • Accepted December 20, 2016

Author Information

  1. LaTonya D. Williams1,*,
  2. Gilad Ofek2,*,
  3. Sebastian Schätzle3,*,
  4. Jonathan R. McDaniel3,*,
  5. Xiaozhi Lu1,*,
  6. Nathan I. Nicely1,
  7. Liming Wu2,
  8. Caleb S. Lougheed2,
  9. Todd Bradley1,4,
  10. Mark K. Louder5,
  11. Krisha McKee5,
  12. Robert T. Bailer5,
  13. Sijy O’Dell5,
  14. Ivelin S. Georgiev6,
  15. Michael S. Seaman7,
  16. Robert J. Parks1,
  17. Dawn J. Marshall1,
  18. Kara Anasti1,
  19. Guang Yang1,
  20. Xiaoyan Nie1,
  21. Nancy L. Tumba8,9,
  22. Kevin Wiehe1,4,
  23. Kshitij Wagh10,
  24. Bette Korber10,
  25. Thomas B. Kepler11,
  26. S. Munir Alam1,4,12,
  27. Lynn Morris8,9,
  28. Gift Kamanga13,
  29. Myron S. Cohen14,
  30. Mattia Bonsignori1,4,
  31. Shi-Mao Xia1,
  32. David C. Montefiori1,15,
  33. Garnett Kelsoe1,16,
  34. Feng Gao1,4,
  35. John R. Mascola5,
  36. M. Anthony Moody1,16,17,
  37. Kevin O. Saunders1,15,
  38. Hua-Xin Liao1,4,
  39. Georgia D. Tomaras1,15,16,18,
  40. George Georgiou3,19, and
  41. Barton F. Haynes1,4,16,
  1. 1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
  2. 2Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA.
  3. 3Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
  4. 4Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  5. 5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
  6. 6Vanderbilt Vaccine Center and Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  7. 7Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
  8. 8Centre for HIV and STIs, National Institute for Communicable Diseases, Johannesburg 2131, South Africa.
  9. 9Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Congella 4013, South Africa.
  10. 10Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
  11. 11Departments of Microbiology and Mathematics & Statistics, Boston University School of Medicine, Boston, MA 02118, USA.
  12. 12Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.
  13. 13University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe, Malawi.
  14. 14Departments of Medicine, Epidemiology, and Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.
  15. 15Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
  16. 16Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.
  17. 17Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.
  18. 18Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
  19. 19Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  1. Corresponding author. Email: barton.haynes{at}dm.duke.edu (B.F.H.); gg{at}che.utexas.edu (G.G.)
  1. * These authors contributed equally to this work.

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