Research ArticleIMMUNE DEVELOPMENT

The checkpoint for agonist selection precedes conventional selection in human thymus

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Science Immunology  24 Feb 2017:
Vol. 2, Issue 8, eaah4232
DOI: 10.1126/sciimmunol.aah4232

Article Information

vol. 2 no. 8

PubMed: 
Published By: 
History: 
  • Received June 24, 2016
  • Revision received November 7, 2016
  • Accepted January 11, 2017

Author Information

  1. Greet Verstichel1,
  2. David Vermijlen2,3,
  3. Liesbet Martens4,
  4. Glenn Goetgeluk1,
  5. Margreet Brouwer3,
  6. Nicolas Thiault5,
  7. Yasmine Van Caeneghem1,
  8. Stijn De Munter1,
  9. Karin Weening1,
  10. Sarah Bonte1,
  11. Georges Leclercq1,
  12. Tom Taghon1,
  13. Tessa Kerre1,
  14. Yvan Saeys4,6,
  15. Jo Van Dorpe7,
  16. Hilde Cheroutre5 and
  17. Bart Vandekerckhove1,*
  1. 1Faculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium.
  2. 2Department of Biopharmacy, Université Libre de Bruxelles (ULB), Boulevard du Triomphe, accès 2, 1050 Brussels, Belgium.
  3. 3Institute for Medical Immunology, ULB, Rue Adrienne Bolland 8, 6041 Gosselies, Belgium.
  4. 4Data Mining and Modeling for Systems Immunology, Vlaams Instituut voor Biotechnologie Inflammation Research Center, Technologiepark 927, 9052 Ghent, Belgium.
  5. 5Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
  6. 6Department of Internal Medicine, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium.
  7. 7Faculty of Medicine and Health Sciences, Department of Medical and Forensic Pathology, Ghent University, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium.
  1. *Corresponding author. Email: bart.vandekerckhove{at}ugent.be

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