Research ArticleAUTOIMMUNITY
LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes
- Qianxia Zhang1,2,
- Maria Chikina3,
- Andrea L. Szymczak-Workman1,2,
- William Horne4,
- Jay K. Kolls4,
- Kate M. Vignali1,2,
- Daniel Normolle5,
- Maria Bettini2,*,
- Creg J. Workman1,2 and
- Dario A. A. Vignali1,2,6,†
- 1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
- 2Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
- 3Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
- 4Richard King Mellon Foundation Institute for Pediatric Research, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.
- 5Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15232, USA.
- 6Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.
- ↵†Corresponding author. Email: dvignali{at}pitt.edu
↵* Present address: Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
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Science Immunology 31 Mar 2017:
Vol. 2, Issue 9, eaah4569
DOI: 10.1126/sciimmunol.aah4569
