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Research ArticleAUTOIMMUNITY
LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes
- Qianxia Zhang1,2,
- Maria Chikina3,
- Andrea L. Szymczak-Workman1,2,
- William Horne4,
- Jay K. Kolls4,
- Kate M. Vignali1,2,
- Daniel Normolle5,
- Maria Bettini2,*,
- Creg J. Workman1,2 and
- Dario A. A. Vignali1,2,6,†
- 1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
- 2Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
- 3Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
- 4Richard King Mellon Foundation Institute for Pediatric Research, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.
- 5Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15232, USA.
- 6Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.
- ↵†Corresponding author. Email: dvignali{at}pitt.edu
↵* Present address: Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
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Science Immunology 31 Mar 2017:
Vol. 2, Issue 9, eaah4569
DOI: 10.1126/sciimmunol.aah4569
Vol. 2, Issue 9, eaah4569
DOI: 10.1126/sciimmunol.aah4569
Qianxia Zhang
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
Maria Chikina
Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Andrea L. Szymczak-Workman
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
William Horne
Richard King Mellon Foundation Institute for Pediatric Research, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.
Jay K. Kolls
Richard King Mellon Foundation Institute for Pediatric Research, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.
Kate M. Vignali
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
Daniel Normolle
Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Maria Bettini
Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
Creg J. Workman
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
Dario A. A. Vignali
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.
