Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids

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Science Immunology  17 Mar 2017:
Vol. 2, Issue 9, eaaj1996
DOI: 10.1126/sciimmunol.aaj1996

Article Information

vol. 2 no. 9

Published By: 
  • Received September 16, 2016
  • Accepted February 2, 2017

Author Information

  1. H. A. McNamara1,
  2. Y. Cai1,
  3. M. V. Wagle1,
  4. Y. Sontani1,
  5. C. M. Roots1,
  6. L. A. Miosge1,
  7. J. H. O’Connor1,
  8. H. J. Sutton1,
  9. V. V. Ganusov2,
  10. W. R. Heath3,
  11. P. Bertolino4,
  12. C. G. Goodnow1,5,
  13. I. A. Parish1,
  14. A. Enders1 and
  15. I. A. Cockburn1,*
  1. 1Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 2601, Australia.
  2. 2Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.
  3. 3Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia.
  4. 4Liver Immunology Program, Centenary Institute and AW Morrow Gastroenterology and Liver Centre, University of Sydney and Royal Prince Alfred Hospital, Locked Bag No. 6, Sydney, New South Wales 2042, Australia.
  5. 5Immunogenomics Laboratory, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia.
  1. *Corresponding author. Email: ian.cockburn{at}


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