Research ArticleMALARIA

Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFH fate bifurcation in malaria

+ See all authors and affiliations

Science Immunology  03 Mar 2017:
Vol. 2, Issue 9, eaal2192
DOI: 10.1126/sciimmunol.aal2192

Article Information

vol. 2 no. 9

Published By: 
History: 
  • Received October 14, 2016
  • Accepted January 23, 2017

Author Information

  1. Tapio Lönnberg1,2,*,
  2. Valentine Svensson1,*,
  3. Kylie R. James3,*,
  4. Daniel Fernandez-Ruiz4,
  5. Ismail Sebina3,
  6. Ruddy Montandon2,
  7. Megan S. F. Soon3,
  8. Lily G. Fogg3,
  9. Arya Sheela Nair3,
  10. Urijah N. Liligeto3,
  11. Michael J. T. Stubbington1,2,
  12. Lam-Ha Ly2,
  13. Frederik Otzen Bagger1,2,5,6,
  14. Max Zwiessele7,
  15. Neil D. Lawrence7,
  16. Fernando Souza-Fonseca-Guimaraes3,
  17. Patrick T. Bunn3,
  18. Christian R. Engwerda3,
  19. William R. Heath4,8,
  20. Oliver Billker2,
  21. Oliver Stegle1,,,
  22. Ashraful Haque3,, and
  23. Sarah A. Teichmann1,2,,
  1. 1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, U.K.
  2. 2Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, U.K.
  3. 3QIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.
  4. 4Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Parkville, Victoria, Australia.
  5. 5Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, U.K.
  6. 6National Health Service Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge, U.K.
  7. 7Department of Computer Science, University of Sheffield, Sheffield, U.K.
  8. 8Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, Victoria, Australia.
  1. Corresponding author. Email: st9{at}sanger.ac.uk (S.A.T.); ashraful.haque{at}qimrberghofer.edu.au (A.H.); stegle{at}ebi.ac.uk (O.S.)
  1. * These authors contributed equally to this work.

  2. These authors contributed equally to this work.

AltMetrics

Article usage

AbstractFullPDF
Mar 20177297385532
Apr 20171416157128
May 201794617494
Jun 201789316795
Jul 201750110551