Research ArticleASTHMA

Natural killer cell–mediated inflammation resolution is disabled in severe asthma

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Science Immunology  10 Mar 2017:
Vol. 2, Issue 9, eaam5446
DOI: 10.1126/sciimmunol.aam5446

Article Information

vol. 2 no. 9

Published By: 
History: 
  • Received December 6, 2016.
  • Accepted January 27, 2017.

Author Information

  1. Melody G. Duvall1,2,
  2. Cindy Barnig3,
  3. Manuela Cernadas1,
  4. Isabell Ricklefs1,
  5. Nandini Krishnamoorthy1,
  6. Nicole L. Grossman1,
  7. Nirav R. Bhakta4,
  8. John V. Fahy4,
  9. Eugene R. Bleecker5,
  10. Mario Castro6,
  11. Serpil C. Erzurum7,
  12. Benjamin M. Gaston8,
  13. Nizar N. Jarjour9,
  14. David T. Mauger10,
  15. Sally E. Wenzel11,
  16. Suzy A. Comhair7,
  17. Andrea M. Coverstone12,
  18. Merritt L. Fajt11,
  19. Annette T. Hastie5,
  20. Mats W. Johansson13,
  21. Michael C. Peters4,
  22. Brenda R. Phillips10,
  23. Elliot Israel1,*,
  24. Bruce D. Levy1,*,,
  25. National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators
  1. 1Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Division of Critical Care Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Department of Chest Diseases, University Hospital of Strasbourg, Strasbourg, France.
  4. 4Division of Pulmonary and Critical Care Medicine, Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
  5. 5Center for Genomics and Personalized Medicine Research, School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
  6. 6Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Pediatrics, Washington University, St. Louis, MO 63110, USA.
  7. 7Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  8. 8Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA.
  9. 9Division of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
  10. 10Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, PA 17033, USA.
  11. 11Pulmonary, Allergy and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
  12. 12Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
  13. 13Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.
  1. Corresponding author. Email: blevy{at}partners.org
  1. * These authors contributed equally to this work.

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