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Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration

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Science Immunology  12 Jan 2018:
Vol. 3, Issue 19, eaal2736
DOI: 10.1126/sciimmunol.aal2736

Article Information

vol. 3 no. 19

Published By: 
  • Received October 24, 2016
  • Revision received September 6, 2017
  • Accepted November 22, 2017

Author Information

  1. Tobias Wertheimer1,2,*,
  2. Enrico Velardi1,*,
  3. Jennifer Tsai1,3,*,
  4. Kirsten Cooper3,
  5. Shiyun Xiao4,
  6. Christopher C. Kloss5,6,,
  7. Katja J. Ottmüller7,
  8. Zeinab Mokhtari7,
  9. Christian Brede7,
  10. Paul deRoos3,
  11. Sinéad Kinsella3,
  12. Brisa Palikuqi5,
  13. Michael Ginsberg8,
  14. Lauren F. Young1,
  15. Fabiana Kreines1,
  16. Sophia R. Lieberman1,
  17. Amina Lazrak1,
  18. Peipei Guo5,
  19. Florent Malard1,
  20. Odette M. Smith1,
  21. Yusuke Shono1,
  22. Robert R. Jenq9,
  23. Alan M. Hanash9,
  24. Daniel J. Nolan8,
  25. Jason M. Butler5,
  26. Andreas Beilhack7,
  27. Nancy R. Manley4,
  28. Shahin Rafii5,
  29. Jarrod A. Dudakov3,10,,§ and
  30. Marcel R. M. van den Brink1,9,,§
  1. 1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  2. 2Division of Hematology and Oncology, Department of Medicine, Freiburg University Medical Center, Albert-Ludwigs-University, 79106 Freiburg, Germany.
  3. 3Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  4. 4Department of Genetics, University of Georgia, Athens, GA 30602, USA.
  5. 5Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.
  6. 6Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  7. 7Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.
  8. 8Angiocrine Bioscience, San Diego, CA 92130, USA.
  9. 9Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  10. 10Department of Immunology, University of Washington, Seattle, WA 98109, USA.
  1. §Corresponding author. Email: jdudakov{at} (J.A.D.); vandenbm{at} (M.R.M.v.d.B.)
  1. * These authors contributed equally to this work.

  2. These authors contributed equally to this work.

  • Present address: Center for Cellular Immunotherapies and Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.


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