Research ArticleALLERGY

Dysregulated invertebrate tropomyosin–dectin-1 interaction confers susceptibility to allergic diseases

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Science Immunology  23 Feb 2018:
Vol. 3, Issue 20, eaam9841
DOI: 10.1126/sciimmunol.aam9841

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Dectin-1 limits allergic responses

Aberrant activation of pattern recognition receptors (PRRs) drives inflammation in autoimmune and allergic diseases. Here, Gour et al. have identified invertebrate tropomyosin from house dust mite and shrimp as a ligand for dectin-1. Dectin-1 is a PRR that has been demonstrated to recognize fungal β-glucans to antifungal immune responses. Here, the authors report that engagement of dectin-1 by invertebrate tropomyosins limits type 2 inflammation and that dectin-1–deficient mice are more prone to allergic airway inflammation. They have also established that expression of dectin-1 is repressed in allergic individuals. By identifying invertebrate tropomyosin orthologs as dectin-1 ligands, the study establishes the importance of dectin-1 in limiting allergic responses.