Research ArticleAUTOIMMUNITY

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

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Science Immunology  02 Feb 2018:
Vol. 3, Issue 20, eaao4013
DOI: 10.1126/sciimmunol.aao4013

Article Information

vol. 3 no. 20

Published By: 
  • Received July 16, 2017
  • Accepted December 4, 2017

Author Information

  1. Slobodan Culina1,2,3,*,
  2. Ana Ines Lalanne1,2,3,*,
  3. Georgia Afonso1,2,3,
  4. Karen Cerosaletti4,
  5. Sheena Pinto5,
  6. Guido Sebastiani6,
  7. Klaudia Kuranda1,2,3,
  8. Laura Nigi6,
  9. Anne Eugster7,
  10. Thomas Østerbye8,
  11. Alicia Maugein1,2,3,
  12. James E. McLaren9,
  13. Kristin Ladell9,
  14. Etienne Larger1,2,3,10,
  15. Jean-Paul Beressi11,
  16. Anna Lissina12,13,
  17. Victor Appay12,13,
  18. Howard W. Davidson14,
  19. Søren Buus8,
  20. David A. Price9,15,
  21. Matthias Kuhn16,
  22. Ezio Bonifacio7,
  23. Manuela Battaglia17,
  24. Sophie Caillat-Zucman18,
  25. Francesco Dotta6,
  26. Raphael Scharfmann1,2,3,
  27. Bruno Kyewski5,
  28. Roberto Mallone1,2,3,10,,
  29. ImMaDiab Study Group
  1. 1INSERM, U1016, Cochin Institute, Paris, France.
  2. 2CNRS, UMR8104, Cochin Institute, Paris, France.
  3. 3Paris Descartes University, Sorbonne Paris Cité, Paris, France.
  4. 4Benaroya Research Institute, Translational Research Program, Seattle, WA 98101, USA.
  5. 5Division of Developmental Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  6. 6Diabetes Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, and Fondazione Umberto di Mario ONLUS, Toscana Life Sciences, Siena, Italy.
  7. 7CRTD-DFG Research Center for Regenerative Therapies Dresden, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
  8. 8Department of International Health, Immunology and Microbiology, Panum Institute, Copenhagen, Denmark.
  9. 9Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
  10. 10Assistance Publique Hôpitaux de Paris, Service de Diabétologie, Cochin Hospital, Paris, France.
  11. 11Centre Hospitalier de Versailles André Mignot, Service de Diabétologie, Le Chesnay, France.
  12. 12Pierre et Marie Curie Paris 6 University, Sorbonne Paris Cité, Département Hospitalo-Universitaire FAST, CR7, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
  13. 13INSERM, U1135, CIMI-Paris, Paris, France.
  14. 14Barbara Davis Center for Diabetes and Integrated Department of Immunology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA.
  15. 15Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  16. 16Institut für Medizinische Informatik und Biometrie, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
  17. 17Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  18. 18Assistance Publique Hôpitaux de Paris, Laboratoire d’Immunologie et Histocompatibilité, Hôpital Saint-Louis, Paris, France.
  1. Corresponding author. Email: roberto.mallone{at}
    1. * These authors contributed equally to this work.

    • Members of the ImMaDiab Study Group are listed in the Supplementary Materials.


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