The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes

Ben S. Wendel; Daniel del Alcazar; Chenfeng He; Perla M. Del Río-Estrada; Benjamas Aiamkitsumrit; Yuria Ablanedo-Terrazas; Stefany M. Hernandez; Ke-Yue Ma; Michael R. Betts; Laura Pulido; Jun Huang; Phyllis A. Gimotty; Gustavo Reyes-Terán; Ning Jiang; Laura F. Su

doi:10.1126/sciimmunol.aan8884

Research ArticleHIV

The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes

Ben S. Wendel¹,*,
Daniel del Alcazar²,³,*,
Chenfeng He⁴,*,
Perla M. Del Río-Estrada⁵,
Benjamas Aiamkitsumrit²,³,
Yuria Ablanedo-Terrazas⁵,
Stefany M. Hernandez¹,
Ke-Yue Ma⁶,
Michael R. Betts ⁷,
Laura Pulido⁸,
Jun Huang⁸,
Phyllis A. Gimotty⁹,
Gustavo Reyes-Terán⁵,
Ning Jiang ⁴,⁶,† and
Laura F. Su ²,³,†

¹McKetta Department of Chemical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.
²Department of Medicine, Perelman School of Medicine, University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.
³Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁴Department of Biomedical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.
⁵Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.
⁶Institute for Cellular and Molecular Biology, College of Natural Sciences, University of Texas at Austin, Austin, TX 78712, USA.
⁷Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁸Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
⁹Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

↵†Corresponding author. Email: laurasu{at}upenn.edu (L.F.S.); jiang{at}austin.utexas.edu (N.J.)

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Immunology 06 Apr 2018:
Vol. 3, Issue 22, eaan8884
DOI: 10.1126/sciimmunol.aan8884

Ben S. Wendel

McKetta Department of Chemical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ben S. Wendel

Daniel del Alcazar

Department of Medicine, Perelman School of Medicine, University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Daniel del Alcazar

Chenfeng He

Department of Biomedical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Chenfeng He

Perla M. Del Río-Estrada

Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Perla M. Del Río-Estrada

Benjamas Aiamkitsumrit

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Benjamas Aiamkitsumrit

Yuria Ablanedo-Terrazas

Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yuria Ablanedo-Terrazas

Stefany M. Hernandez

McKetta Department of Chemical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Stefany M. Hernandez

Ke-Yue Ma

Institute for Cellular and Molecular Biology, College of Natural Sciences, University of Texas at Austin, Austin, TX 78712, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ke-Yue Ma

Michael R. Betts

Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Michael R. Betts

Laura Pulido

Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Laura Pulido

Jun Huang

Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jun Huang

Phyllis A. Gimotty

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gustavo Reyes-Terán

Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Gustavo Reyes-Terán

Ning Jiang

Department of Biomedical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.Institute for Cellular and Molecular Biology, College of Natural Sciences, University of Texas at Austin, Austin, TX 78712, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ning Jiang
For correspondence: Laurasu@upenn.edujiang@austin.utexas.edu

Laura F. Su

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Laura F. Su
For correspondence: Laurasu@upenn.edujiang@austin.utexas.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. eLetters are not edited, proofread, or indexed. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

Publication Date - String

First Publication Date - String

Electronic Publication Date - String

Print Publication Date - String

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes

Plain text

Vertical Tabs

Science Immunology

Article Tools