The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes

Ben S. Wendel; Daniel del Alcazar; Chenfeng He; Perla M. Del Río-Estrada; Benjamas Aiamkitsumrit; Yuria Ablanedo-Terrazas; Stefany M. Hernandez; Ke-Yue Ma; Michael R. Betts; Laura Pulido; Jun Huang; Phyllis A. Gimotty; Gustavo Reyes-Terán; Ning Jiang; Laura F. Su

doi:10.1126/sciimmunol.aan8884

Research ArticleHIV

The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes

Ben S. Wendel¹,*,
Daniel del Alcazar²,³,*,
Chenfeng He⁴,*,
Perla M. Del Río-Estrada⁵,
Benjamas Aiamkitsumrit²,³,
Yuria Ablanedo-Terrazas⁵,
Stefany M. Hernandez¹,
Ke-Yue Ma⁶,
Michael R. Betts ⁷,
Laura Pulido⁸,
Jun Huang⁸,
Phyllis A. Gimotty⁹,
Gustavo Reyes-Terán⁵,
Ning Jiang ⁴,⁶,† and
Laura F. Su ²,³,†

¹McKetta Department of Chemical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.
²Department of Medicine, Perelman School of Medicine, University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.
³Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁴Department of Biomedical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.
⁵Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.
⁶Institute for Cellular and Molecular Biology, College of Natural Sciences, University of Texas at Austin, Austin, TX 78712, USA.
⁷Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁸Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
⁹Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

↵†Corresponding author. Email: laurasu{at}upenn.edu (L.F.S.); jiang{at}austin.utexas.edu (N.J.)

↵* These authors contributed equally to this work.

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Science Immunology 06 Apr 2018:
Vol. 3, Issue 22, eaan8884
DOI: 10.1126/sciimmunol.aan8884

Ben S. Wendel

McKetta Department of Chemical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.

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Daniel del Alcazar

Department of Medicine, Perelman School of Medicine, University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Chenfeng He

Department of Biomedical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.

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Perla M. Del Río-Estrada

Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.

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Benjamas Aiamkitsumrit

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Yuria Ablanedo-Terrazas

Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.

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Stefany M. Hernandez

McKetta Department of Chemical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.

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Ke-Yue Ma

Institute for Cellular and Molecular Biology, College of Natural Sciences, University of Texas at Austin, Austin, TX 78712, USA.

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Michael R. Betts

Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Laura Pulido

Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.

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Jun Huang

Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.

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Phyllis A. Gimotty

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Gustavo Reyes-Terán

Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.

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Ning Jiang

Department of Biomedical Engineering, Cockrell School of Engineering, University of Texas at Austin, Austin, TX 78712, USA.Institute for Cellular and Molecular Biology, College of Natural Sciences, University of Texas at Austin, Austin, TX 78712, USA.

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For correspondence: Laurasu@upenn.edujiang@austin.utexas.edu

Laura F. Su

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For correspondence: Laurasu@upenn.edujiang@austin.utexas.edu

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The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes

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