Research ArticleINFECTIOUS DISEASES

Mitochondrial cyclophilin D regulates T cell metabolic responses and disease tolerance to tuberculosis

See allHide authors and affiliations

Science Immunology  11 May 2018:
Vol. 3, Issue 23, eaar4135
DOI: 10.1126/sciimmunol.aar4135

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Mycobacteria and metabolism

Since the discovery of Mycobacterium tuberculosis (Mtb) over a century ago, great progress has been made in defining mechanisms of host resistance to tuberculosis (TB). By contrast, our understanding of how 90 to 95% of infected individuals live with chronic TB is extremely limited. Here, Tzelepis et al. examine the role of mitochondrial matrix protein cyclophilin D (CypD) in T cells using a mouse model of Mtb infection. CypD-deficient mice were more susceptible to Mtb infection in spite of enhanced Mtb-specific T cell responses, which has no impact on curbing bacterial loads but substantially increased lung immunopathology. Their findings indicate that CypD is a critical checkpoint of T cell metabolism for regulating disease tolerance in TB.