FocusIMMUNODEFICIENCIES

Who regulates whom: ZNF341 is an additional player in the STAT3/TH17 song

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Science Immunology  15 Jun 2018:
Vol. 3, Issue 24, eaat9779
DOI: 10.1126/sciimmunol.aat9779

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Abstract

Deficiency of ZNF341, a transcription factor featuring 12 Cys2His2 zinc fingers that regulates the expression and autoinduction of STAT3 (signal transducer and activator of transcription 3), results in hyper–immunoglobulin E syndrome and defective T helper 17 cell differentiation in humans.

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