ReviewCYTOKINES

Revisiting IL-2: Biology and therapeutic prospects

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Science Immunology  06 Jul 2018:
Vol. 3, Issue 25, eaat1482
DOI: 10.1126/sciimmunol.aat1482

Figures

  • Fig. 1 Dual role of IL-2 in T cell activation.

    IL-2 participates in the induction of immune responses by stimulating proliferation and differentiation of “conventional” T cells and in the control of immune responses by maintaining Treg cells. These two activities likely differ in the kinetics and amount of IL-2 produced. MHC, major histocompatibility complex; TCR, T cell receptor; APC, antigen-presenting cell.

    CREDIT: A. KITTERMAN/AAAS
  • Fig. 2 Cellular targets of IL-2 action.

    In addition to conventional T cells and Treg cells, IL-2 acts on NK cells and ILCs.

    CREDIT: A. KITTERMAN/AAAS
  • Fig. 3 Structure of IL-2/IL-2R complex.

    A ribbon diagram depiction of the crystal structure of IL-2 with its trimeric receptor shows how the cytokine interacts with each of the three chains of the receptor. This illustration was adapted from the protein structure (89).

    CREDIT: A. KITTERMAN/AAAS