Research ArticleANTIBODIES

Enhancing FcγR-mediated antibody effector function during persistent viral infection

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Science Immunology  21 Sep 2018:
Vol. 3, Issue 27, eaao3125
DOI: 10.1126/sciimmunol.aao3125

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Giving antibodies a boost

Persistent immune activation during chronic infections is often associated with increased generation and deposition of immune complexes. The actions of antibody-based drugs can therefore be severely impaired in individuals with chronic infections. Using lymphocytic choriomeningitis virus (LCMV) as a model of chronic infection, Wieland et al. have examined how to enhance antibody functions in this setting. They found that the ability of antibodies to deplete target cells is dependent on antigen expression levels. Further, they also found that afucosylation of antibodies directed against CD4 and CD8α enhanced the ability of these antibodies to deplete CD4+ and CD8+ T cells in mice persistently infected with LCMV. Whether afucosylation can be universally used to enhance antibody functions during chronic infections remains to be seen.