Research ArticleIMMUNOGENOMICS

Molecular diversification of regulatory T cells in nonlymphoid tissues

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Science Immunology  14 Sep 2018:
Vol. 3, Issue 27, eaat5861
DOI: 10.1126/sciimmunol.aat5861

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Mapping Treg regulomes

Technological advances are allowing immunologists to study rare populations of immune cells that take residence in various tissues including adipose tissue, skin, and the lung. Here, DiSpirito et al. have generated transcriptomes and chromatin accessibility maps of mouse regulatory T cells (Tregs) that reside in visceral adipose tissue, muscle, and the colon and compared them with the profiles generated from splenic Tregs. They have used these data sets to define transcriptional networks that are shared by all these populations and to identify networks that are unique to one or more tissue-resident Treg populations.