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October 2018
Vol 3, Issue 28

About The Cover

Cover image expansion

ONLINE COVER Brush Strokes. The cover features an immunofluorescence image showing three brush cells in mouse tracheal epithelium that co-express the chemosensory cell marker doublecortin-like kinase 1 (DCLK1; green) and the cytokine interleukin-25 (IL-25; red). Airway brush cells display a characteristic tuft of microvilli at their apical tip and express receptors also found in taste-sensing cells. Bankova et al. report that aeroallergen inhalation induces an increase in IL-25–producing brush cells that depends on the lipid mediator leukotriene E4 activating the cysteinyl leukotriene 3 receptor. [CREDIT: BANKOVA ET AL./SCIENCE IMMUNOLOGY]