Research ResourcesHEPATITIS

Multifactorial heterogeneity of virus-specific T cells and association with the progression of human chronic hepatitis B infection

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Science Immunology  08 Feb 2019:
Vol. 4, Issue 32, eaau6905
DOI: 10.1126/sciimmunol.aau6905

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Mapping the T cell response to hepatitis B

Unlike evaluating antibody responses to infections, studying T cell responses has always been more complicated. A significant hurdle here continues to be the development of reagents to identify and characterize pathogen-specific T cells. Here, Cheng et al. have generated a comprehensive panel of peptide class I major histocompatibility complex tetramers to study CD8+ T cells that recognize hepatitis B virus (HBV). Using HBV-specific tetramers in conjunction with mass cytometry, they have documented functional states of HBV-specific CD8+ T cells in individuals with chronic HBV infection. The tetramer panels generated here to study HBV-specific T cells should be of broad utility to the HBV research community.