Science Immunology

Supplementary Materials

Supplementary Material for:

Mitochondrial cyclophilin D regulates T cell metabolic responses and disease tolerance to tuberculosis

Fanny Tzelepis, Julianna Blagih, Nargis Khan, Joshua Gillard, Laura Mendonca, Dominic G. Roy, Eric H. Ma, Philippe Joubert, Russell G. Jones, Maziar Divangahi*

*Corresponding author. Email: maziar.divangahi{at}mcgill.ca

Published 11 May 2018, Sci. Immunol. 3, eaar413 (2017)
DOI: 10.1126/sciimmunol.aar4135

This PDF file includes:

  • Material and Methods
  • Fig. S1. CyD-deficient macrophages are more resistance to necrosis after infection with virulent strain of Mtb.
  • Fig. S2. CypD regulates T cell responses independent of sex during Mtb infection.
  • Fig. S3. CypD-deficient mice presents enhanced T cell response after infection with Mtb.
  • Fig. S4. CypD minimally affects innate immune cells and B cell responses after Mtb infection.
  • Fig. S5. CypD regulates T cells proliferation and activation.
  • Fig. S6. CypD regulates T cell metabolism.

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