Table 1 Pathways specifically up-regulated in clonal expanded CD8+ T cells with Ab treatment (day 11).

Genes specifically up-regulated in monotherapy or combination therapy compared with isotype control were analyzed using Illumina Gene Ontology Engine. Jak, Janus kinase; STAT, signal transducers and activators of transcription.

TreatmentPathwayP value
Anti–PD-1 + Anti-GITRAdaptive immune response1.50 × 10−08
Cell cycle5.80 × 10−07
Metabolism of lipids and lipoproteins3.00 × 10−04
Anti–PD-1Lymphocyte activation2.30 × 10−05
Gene targets for miR-124u (T cell activation)1.80 × 10−05
Jak-STAT signaling pathway3.00 × 10−04
Anti-GITRGlucose metabolism8.20 × 10−10
Protein metabolism7.50 × 10−08
The citric acid cycle and respiratory electron transport3.90 × 10−06