March 2021
Vol 6, Issue 57
  • First Release: Research Articles

    • SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses

      SARS-CoV-2 mutations in MHC-I epitopes identified by deep viral sequencing evade CTL responses through decreased peptide-MHC-I binding.

    • Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19

      MIS-C is defined by lymphocyte activation, including elevated plasmablast frequencies and marked activation of CX3CR1+ CD8+ T cells.

  • Research Articles

  • Editor's Choice

    • The ABCs of ovarian cancer immunology: IgA, B cells, and CTLs

      Intratumoral B cells in ovarian cancers produce IgA, which binds tumor antigens and inhibit tumor growth through myeloid cell–dependent mechanisms or by neutralization of secreted factors, and by antigen-nonspecific binding to poly-Ig receptor on cancer cells leading to transcytosis, which sensitizes the cells for CTL killing.

About The Cover

Cover image expansion

ONLINE COVER Activating Acetylcholine Production. This month's cover shows a section of mouse jejunum prepared seven days after infection with the helminth parasite Nippostrongylus brasiliensis. Hyperplasia of both yellow goblet cells (stained with the UEA-I lectin) and magenta tuft cells (expressing doublecortin-like kinase 1) is observed as part of the host immune response to this infection. Roberts et al. found that ILC2 synthesis and secretion of the neurotransmitter acetylcholine contributed to effective expulsion of the parasites. [CREDIT: NAVEEN PARMAR/NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY]