Contents
April 2021
Vol 6, Issue 58
Vol 6, Issue 58
First Release
- SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
SARS-CoV-2 induces JAK-STAT1–dependent complement C3 transcription and processing by a cell-intrinsic alternative pathway convertase.
Research Articles
- Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses
The magnitude of antitumor abscopal effects is determined by the sequence of checkpoint blockade in relation to local tumor irradiation.
- Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT
DC-SCRIPT is a key transcription factor controlling type 1 conventional dendritic cell fate and function.
- Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells
pDCs recognize cells infected with human cytomegalovirus and respond with a unique prolonged activation program.
Editors' Choice
- Brain tumor T cells inhibited by their natural KLR(B1) instinct
Charting the gene-expression landscape of glioma-infiltrating T cells demonstrates that these T cells can express NK cell receptors, which inhibit the killing of glioma cells.
- Atypical is the new norm, for B cells and the rest of us
An unusual form of activated B cells in adults is described, called atypical B cells, both in the steady state and after vaccination.
About The Cover
ONLINE COVER Splenic DCs Sticking to the DC-SCRIPT. This month's cover captures the expression of the transcriptional regulator DC-SCRIPT in the mouse spleen using a dtTomato reporter allele. This confocal microscopy image highlights DC-SCRIPT expression in dendritic cells (DCs, red) that are embedded in the T cell zone (CD3, blue), surrounded by B cells (IgM, green) and the marginal zone (CD169, yellow). DC-SCRIPT is also expressed in DCs and macrophages in the red pulp. Zhang et al. found that DC-SCRIPT controls the development and function of type 1 conventional DCs. [CREDIT: WANG CAO AND SHENGBO ZHANG]
