Contents
June 2021
Vol 6, Issue 60
Vol 6, Issue 60
First Release
- COVID-19 vaccine side effects: The positives about feeling bad
The side effects of SARS-CoV-2 vaccines are often troubling but may merely reflect transient production of type I interferons, a normal physiological response to contact with invading microorganisms.
- SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques
SARS-CoV-2 vaccines are well-tolerated and highly immunogenic in infant rhesus macaques
- Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients
Kidney transplant and dialysis patients showed a diminished humoral response and B cell memory formation upon vaccination with BNT162b2.
Focus
- Getting toGether in Germinal centers
Ggt5 cleaves the ligand of P2RY8 in lymph node follicles and generates a gradient that supports B cell confinement to germinal centers.
Research Articles
- Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals
Sustained activation of mTORC1 at late endosomes in primary CD4+ T cell responses of older individuals impairs T helper cell function.
- Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency
OAS1-GOF/RNase L–mediated RNA cleavage caused an interferon-induced hyperinflammatory monocyte and B cell immunodeficiency.
- Assembly of a spatial circuit of T-bet–expressing T and B lymphocytes is required for antiviral humoral immunity
T-bet–expressing T and B lymphocytes form a spatiotemporal circuit that enables optimal antiviral humoral immunity.
- All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages
All-trans retinoic acid induces inflammatory myeloid cells to enhance antitumor adaptive immunity after radiation therapy.
- Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione
This work establishes how P2RY8 ligand is exported and degraded to regulate lymphocyte behavior in lymphoid follicles and bone marrow.
- Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3+CD8+ Tregs
Intestinal cDC1 drive the generation of FoxP3+CD8+ Tregs to maintain tolerance to epithelial-derived self-antigen.
Editors' Choice
- Anti-body antibodies in COVID-19
A new high-throughput screening technique detected autoantibodies in COVID-19 patients specific for many different immunomodulatory extracellular and cell surface proteins, several of which were associated with disease severity and clinical outcomes.
- It’s good to have Gremlins in the zone
A unique subset of Gremlin1-expressing fibroblastic reticular cells mediate cDC homeostasis and functionality within lymph nodes.
About The Cover
ONLINE COVER Chemical Confinement of Germinal Center B Cells. This month's cover is an immunofluorescence image showing the spleen of a preimmunized mouse injected one day earlier with B cells (in green) expressing the human P2RY8 receptor. Gallman et al. observed that retention of the transferred B cells in germinal centers, defined by a network of follicular dendritic cells (in red), was maintained by a repulsive gradient of S-geranylgeranyl-ʟ-glutathione (GGG), a P2RY8 ligand exported from B cells in the outer follicle via the Abcc1 transporter protein. A Focus commentary by Stoler-Barak and Shulman explores how GGG gradients are established and maintained to enable germinal centers to support the affinity maturation of B cell–encoded immunoglobulins. [CREDIT: GALLMAN ET AL./SCIENCE IMMUNOLOGY]
