Contents
July 2019
Vol 4, Issue 37
Vol 4, Issue 37
Focus
- Should I stay or should I go—Reconciling clashing perspectives on CD4+ tissue-resident memory T cells
Two recent studies on CD4+ T cells in nonlymphoid tissues reveal a combination of memory cell retention and emigration. See the related Research Article by Klicznik et al.
Research Articles
- Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells
Disulfide-stabilized MHC class I are empty peptide-receptive molecules that rapidly load peptide and improve T cell detection. See the related Research Article by Moritz et al. in this issue.
- High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A*02:01 molecules
Functionally empty and peptide-receptive soluble HLA-A*02:01 enables high-throughput analysis of TCR binding to peptide-MHCs. See the related Research Article by Saini et al. in this issue.
- Engineering nanoparticles to locally activate T cells in the tumor microenvironment
Engineered antibody nanoparticles overcome immunological tolerance to PDL1 blockade therapy.
- Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals
Human blood and lymph contain circulating CD4+CD103+ cutaneous resident memory T cells that can seed distant skin sites. See the related Focus by Carbone and Gebhardt.
Review
- The anatomy and immunology of vasculature in the central nervous system
This review discusses the immunology of central nervous system vasculature from a neuroanatomical perspective.
Editors' Choice
- Adding intestinal insult to skin injury
Mechanical skin injury promotes food allergy.
- Binding is not enough; autoantibodies do more to garner complements
Pathogenic autoantibodies in neuromyelitis optica require antigen array assembly and a specific epitope to initiate robust complement activation.
About The Cover
ONLINE COVER Mobilizing CD4+ Skin T Cells. This month's cover shows brown-stained CD4+ T cells in a section of human skin. Some of these CD4+ cells are resident memory T cells (TRM) present in the dermis. Klicznik et al. identified CD4+CLA+CD103+T cells in human blood with multiple features in common with CD4+ skin TRM. These observations establish that cutaneous CD4+ TRM are capable of "going mobile" and migrating to distant skin sites. [CREDIT: PETER A. MORAWSKI]
