July 2021
Vol 6, Issue 61

About The Cover

Cover image expansion

ONLINE COVER Unintended Consequences. This month's cover shows human liver biopsy tissue from a cancer patient who experienced a hepatic immune-related adverse event (irAE) after checkpoint blockade therapy with antibodies to PD-1 and CTLA-4. Circumscribed areas of immune cell infiltration include a population of CD15+ granulocytes (brown). Siwicki et al. investigated mechanisms of immunotherapy-driven adverse events in a mouse model of cancer, specifically focusing on hepatitis, and found that tissue-resident macrophages and neutrophils drove irAE hepatotoxicity. Similar immune processes were detected in patients experiencing irAEs after cancer immunotherapy. [CREDIT: SIWICKI ET AL./SCIENCE IMMUNOLOGY]