Contents
July 2020
Vol 5, Issue 49
Vol 5, Issue 49
First Release: Research Articles
- Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
Single-cell RNA sequencing of blood immune cells reveals type I interferon-associated hyper-inflammation in severe COVID-19.
Focus
- Human effector T cells express TOX—Not so “TOX”ic after all
TOX expression is not restricted to exhausted T cells but is a characteristic of all human effector CD8+ T cells (see the related Research Article by Sekine et al.).
Research Articles
- The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity
HEM1 deficiency causes heritable autoimmunity and immunodeficiency.
- TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells
The transcription factor TOX is not exclusively linked to T cell exhaustion (see the related Focus by Utzschneider and Kallies).
- Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease
A human monoclonal antibody shows potential to prevent or treat acute flaccid myelitis associated with enterovirus D68 infection.
Review
- Human inborn errors of immunity: An expanding universe
This Review summarizes recent advances in the molecular, cellular, and clinical characterization of human inborn errors of immunity.
Editors' Choice
- Finding Camel-ot: A Holy Grail against pandemic SARS-CoV-2?
Engineered camelid antibody multimers can potently block SARS-CoV-2 viral entry.
- Let’s talk about sex
Complement gene variation drives sex biases in autoimmune disease.
About The Cover
ONLINE COVER Frozen Footprints of Antibody Fabs. This month's cover features a 3D reconstruction of the capsid surface of human enterovirus D68 (EV-D68), a virus linked to an emerging polio-like illness called acute flaccid myelitis (AFM). The blue and gold patches represent the distinct binding sites on the icosahedral capsid (colored in cyan) occupied by two neutralizing human monoclonal antibodies to EV-D68 identified by Vogt et al. The image was generated by cryo–electron microscopy of immune complexes formed by mixing virions with a 200-fold molar excess of antibody Fab fragments. The antibody depicted in blue is a potential therapeutic agent in human AFM based on its broad reactivity with EV-D68 clades and its ability to protect mice in a model of EV-D68–induced neurologic disease. [CREDIT: KARA JIANING FU/PURDUE UNIVERSITY]
