Contents
July 2021
Vol 6, Issue 61
Vol 6, Issue 61
First Release
- Cross-reactive antibodies against human coronaviruses and the animal coronavirome suggest diagnostics for future zoonotic spillovers
Cross-reactive antibodies present after SARS-CoV-2 infection can distinguish COVID-19 patients from uninfected individuals.
- A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates
An adjuvanted monomeric RBD immunogen induces immunogenicity and protective immunity against SARS-CoV-2 in rhesus macaques.
- CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients
T cells specific for conserved coronavirus antigens are preferentially expanded in COVID-19 patients with mild disease.
Editorial
- Implications of defective immune responses in SARS-CoV-2–vaccinated organ transplant recipients
Organ transplant patients have poor immune responses to COVID-19 vaccines; thus, designing vaccine strategies to protect this vulnerable population from SARS-CoV-2 infection is crucial.
Focus
- Subsetting the subsets: Heterogeneity and developmental relationships of T cells in human tumors
High-dimensional profiling approaches inform developmental relationships between tumor-infiltrating lymphocyte subpopulations.
Research Articles
- The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit
Chemerin restricts cold-induced IL-33 production by beige adipocytes, impairing beige fat’s ability to dissipate excess energy stores.
- Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2
A γδ TCR senses metabolic tumor reprogramming through recognition of EphA2.
- Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation
Pax5 controls the generation, proliferation, and survival of all mature B cells by promoting PI3K signaling via PTEN down-regulation.
- Unstable regulatory T cells, enriched for naïve and Nrp1neg cells, are purged after fate challenge
Lymphophenic fate challenge purges incompletely committed regulatory T cells, a subset enriched for naïve neuropilin-1–negative Treg.
- OAS1/RNase L executes RIG-I ligand–dependent tumor cell apoptosis
5′-Triphosphate RNA–induced apoptosis consists of a RIG-I–dependent priming and an OAS1/RNase L–dependent effector phase.
- Extrathymic Aire-expressing cells support maternal-fetal tolerance
Maternal extrathymic Aire-expressing cells support maternal-fetal tolerance and prevent intrauterine growth restriction in mice.
- In vivo reprogramming of pathogenic lung TNFR2+ cDC2s by IFNβ inhibits HDM-induced asthma
The IFNβ-ERK2-FAO pathway promotes tolerance in lung TNFR2+ cDC2s.
- KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target
Blockade of KIR3DL3 is an immunotherapy for human cancers.
- NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity
NF-κB and IRF1 coordinate intratumoral cDC1 maturation and control of immunogenic tumor growth.
- Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy
Resident macrophages and recruited neutrophils cause toxicities in tumor-free tissues after immunotherapy.
- The m6A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis
The m6A “reader” IMP2 promotes cytokine-induced kidney autoimmunity by posttranscriptional control of C/EBPβ/δ transcription factors.
Editors' Choice
- Lost in post-translational modification—Dengue virus writes its own sequel
Elevated frequency of afucosylated IgG1 antibodies during dengue virus infection is associated with prior infection and predicts severe disease.
- Fishing for a complement signal in the germinal center
Complement signaling on B cells affects germinal center dynamics.
About The Cover
ONLINE COVER Unintended Consequences. This month's cover shows human liver biopsy tissue from a cancer patient who experienced a hepatic immune-related adverse event (irAE) after checkpoint blockade therapy with antibodies to PD-1 and CTLA-4. Circumscribed areas of immune cell infiltration include a population of CD15+ granulocytes (brown). Siwicki et al. investigated mechanisms of immunotherapy-driven adverse events in a mouse model of cancer, specifically focusing on hepatitis, and found that tissue-resident macrophages and neutrophils drove irAE hepatotoxicity. Similar immune processes were detected in patients experiencing irAEs after cancer immunotherapy. [CREDIT: SIWICKI ET AL./SCIENCE IMMUNOLOGY]
