Contents
March 2021
Vol 6, Issue 57
Vol 6, Issue 57
First Release: Research Articles
- SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses
SARS-CoV-2 mutations in MHC-I epitopes identified by deep viral sequencing evade CTL responses through decreased peptide-MHC-I binding.
- Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19
MIS-C is defined by lymphocyte activation, including elevated plasmablast frequencies and marked activation of CX3CR1+ CD8+ T cells.
Research Articles
- Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths
Synthesis of acetylcholine by group 2 innate lymphoid cells is important for optimal immune responses to helminth infection.
- The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity
Activated ILC2s use the ChAT-acetylcholine pathway to enhance their cytokine production and promote helminth expulsion.
- Bispecific antibodies targeting mutant RAS neoantigens
Bispecific T cell–engaging antibodies capable of specifically killing cancer cells expressing mutant RAS neoantigens were generated.
Editor's Choice
- The ABCs of ovarian cancer immunology: IgA, B cells, and CTLs
Intratumoral B cells in ovarian cancers produce IgA, which binds tumor antigens and inhibit tumor growth through myeloid cell–dependent mechanisms or by neutralization of secreted factors, and by antigen-nonspecific binding to poly-Ig receptor on cancer cells leading to transcytosis, which sensitizes the cells for CTL killing.
- Immunological yin-yang after pregnancy
Pregnancy induces both humoral sensitization and T cell tolerance to paternal tissues.
About The Cover
ONLINE COVER Activating Acetylcholine Production. This month's cover shows a section of mouse jejunum prepared seven days after infection with the helminth parasite Nippostrongylus brasiliensis. Hyperplasia of both yellow goblet cells (stained with the UEA-I lectin) and magenta tuft cells (expressing doublecortin-like kinase 1) is observed as part of the host immune response to this infection. Roberts et al. found that ILC2 synthesis and secretion of the neurotransmitter acetylcholine contributed to effective expulsion of the parasites. [CREDIT: NAVEEN PARMAR/NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY]
