Contents
October 2020
Vol 5, Issue 52
Vol 5, Issue 52
First Release: Research Article and Report
- Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients
Saliva is an alternative biofluid to serum for detecting and monitoring IgG to SARS-CoV-2 spike and RBD antigens in COVID-19.
- Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients
IgM and IgA responses to SARS-CoV-2 RBD in severe COVID patients decay rapidly, while IgG responses persist for over 3 months.
Editorials
- Celebrating 20 years of FOCIS
FOCIS leaders discuss the challenges and opportunities that lie ahead for the society.
- Two decades of bridging immunological divides
The two cofounders of FOCIS recall some of the events surrounding the launch of the federation in 2001.
Research Articles
- Itaconate controls the severity of pulmonary fibrosis
The ACOD1/itaconate axis is a pulmonary regulatory pathway that controls the severity of fibrosis and is a potential therapeutic target in IPF.
- A distinct GM-CSF+ T helper cell subset requires T-bet to adopt a TH1 phenotype and promote neuroinflammation
A GM-CSF+ T helper cell subset develops from naïve precursors and switch to a TH1 phenotype during neuroinflammation.
- Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation
Degradation of tissue debris and recovery from neuroinflammatory disease are impaired in Atg7-deficient microglia, a process mirrored by aging.
- A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses
CD49a+CD16− NK cells from the liver and contact dermatitis lesions specifically recognize antigens and contribute to adaptive immunity.
- Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes
Immunity to inhaled antigens is governed by inflammatory signals that alter the composition of DC subsets within the NALTs.
- IL-22–induced cell extrusion and IL-18–induced cell death prevent and cure rotavirus infection
IL-22 drives intestinal epithelial cell extrusion and can impede rotavirus infection when combined with IL-18.
- Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis
Liver metastasis suppresses systemic tumor-specific immunity and contributes to the resistance to checkpoint immunotherapy.
Editors' Choice
- Aging Tregs need DCAFinating
Loss of DCAF1 and resulting ROS leads to Treg aging and inflammation.
About The Cover
ONLINE COVER Bridging Divides. This month’s cover highlights the 20th anniversary of the Federation of Clinical Immunology Societies (FOCIS), a Strategic Contributor to Science Immunology. The cover image shows the Verrazzano-Narrows Bridge in New York City. Excerpts of interviews with FOCIS cofounders David Hafler and Garry Fathman are featured in an Editorial that provides a behind-the-scenes look at the events that led to the formation of FOCIS and how the organization continues to pursue its mission of building bridges within the immunology community. A second Editorial by Roncarolo and Anderson discusses how FOCIS has responded to the COVID-19 pandemic and the aspirations the society has for its future. [CREDIT: RAFAEL MACIA/SCIENCE SOURCE]
