Contents
April 2020
Vol 5, Issue 46
Vol 5, Issue 46
Research Articles
- Organ-specific isoform selection of fatty acid–binding proteins in tissue-resident lymphocytes
Tissue-resident cells exhibit tissue-specific overlays to the TRM cell residency program that includes flexible FABP isoform selection tailored to the tissue of lodgment.
- Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance
Salivary gland memory CD8+ T cells use distinct motility modes and cooperate with tissue macrophages for organ surveillance.
Editors' Choice
- Learning from our immunological history: What can SARS-CoV teach us about SARS-CoV-2?
The current global pandemic reinforces the importance of basic research and mechanistic human immunology.
- Sex drives Tregs into fat
Androgens promote inflammation in visceral adipose tissue (VAT), leading to the expansion of a distinct IL-33 producing stromal population and recruitment of Tregs.
About The Cover
ONLINE COVER Foraging for Fatty Acids. This month's cover illustration depicts high fat content foods that are a source of fatty acids, one of the sources of metabolic fuel for T lymphocytes. During and following resolution of infection, some circulating memory T cells in the vasculature enter tissues and stay lodged in tissues as long-term residents. These sentinel T cells have been termed tissue-resident memory T (TRM) cells. Frizzell et al. compared the expression of fatty acid-binding proteins (FABPs) by TRM cells from different mouse organs and observed that the FABP profile of TRMs depends on where they are housed. [CREDIT: SEBASTIAN CRUZ GOMEZ]
