Contents
October 2019
Vol 4, Issue 40
Vol 4, Issue 40
Focus
- Lifting the veil on macrophage diversity in tissue regeneration and fibrosis
Sommerfeld et al. have used single-cell RNA sequencing to unravel the role of macrophages in driving tissue repair and fibrosis.
- Going green with solar-powered ILC3 homeostasis
Circadian clock proteins BMAL1 and REV-ERBα harmonize the development and function of ILC3 (see related articles by Teng et al. and Wang et al.).
Research Articles
- Neutrophil extracellular traps drive inflammatory pathogenesis in malaria
NETs contribute to malaria by promoting emergency granulopoiesis and endothelial binding of parasitized erythrocytes.
- Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue
Intratumoral physical engagement of T cells with immunosuppressive neutrophils is associated with reduced effector function.
- Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory
Meningeal γδ T cells are biased toward IL-17 production and control hippocampal synaptic plasticity and short-term memory.
- Interleukin-36γ–producing macrophages drive IL-17–mediated fibrosis
Single-cell RNAseq defines macrophage phenotypes in fibrotic biomaterial environments (see the related Focus by Perciani and MacParland).
- A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut
Circadian regulation is important for intestinal homeostasis of group 3 innate lymphoid cells (see the related Focus by Mortha and Research Article by Wang et al..).
- Circadian rhythm–dependent and circadian rhythm–independent impacts of the molecular clock on type 3 innate lymphoid cells
Clock protein REV-ERBα influences development of type 3 innate lymphoid cells in a circadian-independent manner (see the related Focus by Mortha and Research Article by Teng et al.).
Editors' Choice
- Antibiotics bug the immune response
Changes in the gut microbiome caused by antibiotics can impair immune responses to influenza vaccination.
- They Mite B GCs
T follicular regulatory cells restrain and refine germinal center responses in vivo.
About The Cover
ONLINE COVER Clock-Watching Intestinal ILC3s. On this month's cover is a sundial, one of the earliest methods to keep track of time. Teng et al. and Wang et al. found that expression of several key genes in murine intestinal group 3 innate lymphoid cells (ILC3s) exhibited circadian oscillation. Deletion of key circadian clock genes in mice compromised intestinal ILC3 development and function. The roles that clock genes play in ILC3 biology are discussed by Burrows and Mortha in a related Focus. [CREDIT: ISTOCK.COM/DBENCEK]
