Contents
May 2021
Vol 6, Issue 59
Vol 6, Issue 59
First Release: Research Article
- Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection
Increased complement activation is observed in COVID-19 compared to non-COVID respiratory illness, and is a key marker of organ failure.
Focus
- CMV, MHC-E, and the quest for an unconventional AIDS vaccine
A genetic alteration in cytomegalovirus caused by an inversion-deletion event during tissue culture passage opens an unconventional path toward an HIV vaccine.
Research Articles
- Targeting monoamine oxidase A for T cell–based cancer immunotherapy
Monoamine oxidase A (MAO-A) restrains antitumor T cell immunity, suggesting potential use of MAO-A inhibitors in cancer immunotherapy.
- Selective Janus kinase inhibition preserves interferon-λ–mediated antiviral responses
TYK2 is required for efficient IFN-α/β signaling but dispensable for IFN-λ–mediated antiviral protection in epithelial cells.
- IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage
IL-1 acts on stromal and innate lymphoid cells to coordinate the repair response to distinct types of intestinal damage.
- The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation
Radiation activates AIM2 and NLRP3 inflammasomes to enhance IL-1 signaling on DCs, leading to antitumor immunity.
Editors' Choice
- A T-rojan horse strategy for cancer immunotherapy
CDK4/6 inhibitor–treated breast cancer cells recruit T cells via metabolic stress-induced chemokines.
About The Cover
ONLINE COVER Stromal Cell Specialization. This month's cover shows dual in situ hybridization detection of mRNA for R-spondin 3 (Rspo3) and the alpha chain of the platelet-derived growth factor receptor (Pdgfra) in mouse colon sections on day 11 after infection with Citrobacter rodentium. Pdgfra (red) is expressed in subepithelial fibroblasts while Rspo3 (blue) is selectively expressed in a subset of Grem1+ mesenchymal cells in the muscularis mucosae layer. Cox et al. identified IL-1–induced expression of R-spondin 3, a Wnt signaling pathway agonist, as a key contributor to epithelial restitution. [CREDIT: CHRISTIAN B. COX/GENENTECH, INC.]
