Research ArticleHIV

Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies

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Science Immunology  29 Jul 2016:
Vol. 1, Issue 1, pp. aag0851
DOI: 10.1126/sciimmunol.aag0851

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Setting the stage for HIV vaccines

Some HIV-infected individuals produce antibodies that can target multiple HIV strains—broadly neutralizing antibodies. Moody et al. now compare HIV-infected individuals who produce these antibodies with those who do not. They find that broadly neutralizing antibody production associates with particular immune traits, including a higher frequency of autoantibodies, fewer regulatory T cells, and more circulating memory T follicular helper cells. Vaccine protocols that can mimic these immune perturbations may therefore promote induction of broadly neutralizing antibodies and lead to a more successful immune response to HIV.