Contents
August 2016
Vol 1, Issue 2
Vol 1, Issue 2
Focus
- A one-protein signaling pathway in the innate immune system
Group A Streptococcus protease SpeB directly binds and activates IL-1β.
Research Articles
- Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor
A single T cell receptor can give rise to two distinct T cell types at distinct anatomical locations.
- IL-1β is an innate immune sensor of microbial proteolysis
A microbial protease directly activates IL-1β, resulting in an inflammasome-independent innate immune response.
- ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways
ZBP1 activates the NLRP3 inflammasome and programmed cell death.
- Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients
PMN-MDSC in cancer patients can be distinguished from neutrophils by a genomic signature and by expression of the LOX-1 receptor.
About The Cover
ONLINE COVER LOXing onto Neutrophils. Shown is a conceptual image of a polymorphonuclear cell (PMN). Condamine et al. report that LOX-1 can identify and functionally differentiate immunoregulatory PMN-MDSCs from proinflammatory PMN neutrophils, which may allow specific targeting for cancer immunotherapy. [CREDIT: 3D4Medical/Science Source]