Contents
September 2016
Vol 1, Issue 3
Vol 1, Issue 3
Review
- The intersection of radiotherapy and immunotherapy: Mechanisms and clinical implications
Radiotherapy and immunotherapy cooperate to generate antitumor immune responses for therapeutic gain.
Research Articles
- Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation
Arc/Arg3.1 accelerates DC migration by coordinating cytoskeletal changes in response to inflammatory challenges.
- Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance
A secreted bacterial protein protects worms and mice from Salmonella pathogenesis.
- Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation
CD69 on activated T cells interacts with Myl9/12 expressed in inflamed airways, establishing tissue inflammation.
- Class I HLA haplotypes form two schools that educate NK cells in different ways
Individuals heterozygous for HLA haplotypes have increased NK cell diversity because of distinct education pathways.
- The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn’s disease
RORα contributes to the profibrotic response in the gut in a mouse model of infection-induced gut inflammation.
About The Cover
ONLINE COVER ILCs Bust a Gut. Shown is an immunofluorescence image of a cecal section stained for collagen (magenta) and nuclei (DAPI, cyan). Lo et al. report that infection-induced gut fibrosis was attenuated in mice lacking group 3 innate lymphoid cells. [CREDIT: Bernard Lo/The Biomedical Research Centre, University of British Columbia]