Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation

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Science Immunology  23 Sep 2016:
Vol. 1, Issue 3, pp. eaaf8665
DOI: 10.1126/sciimmunol.aaf8665

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Dendritic cell migration reform

Dendritic cells are the messengers of the immune system, transporting antigens from sites of inflammation to the lymph organs that serve as central hubs for immune activation. Ufer et al. have identified a neuronal plasticity molecule—activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1)—that is expressed in migratory dendritic cells in the skin. Arc/Arg3.1 regulates cytoskeletal changes in dendritic cells, accelerating migration in response to inflammation. Moreover, Arc/Arg3.1 was required for inducing T cell responses in two different disease models—experimental autoimmune encephalitis and allergic contact dermatitis. Targeting Arc/Arg3.1 may therefore be a therapeutic strategy to modify dendritic cell immunotherapy.

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