Contents

Research Articles

• Inhibition of HDAC8 and HDAC9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to TLR ligands

  By James A. Sanford, Ling-Juan Zhang, Michael R. Williams, Jon A. Gangoiti, Chun-Ming Huang, Richard L. Gallo

  Science Immunology28 Oct 2016 Full AccessRestricted Access

  Microbial short-chain fatty acids inhibit HDAC activity and contribute to keratinocyte-triggered skin inflammation.

  • Editor's Summary
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• Type I interferon suppresses virus-specific B cell responses by modulating CD8⁺ T cell differentiation

  By E. Ashley Moseman, Tuoqi Wu, Juan Carlos de la Torre, Pamela L. Schwartzberg, Dorian B. McGavern

  Science Immunology21 Oct 2016 Full AccessRestricted Access

  Type I interferon–driven CD8⁺ T cells suppress neutralizing antibody production during chronic LCMV infection. See related Research Articles by Fallet et al. and Sammicheli et al. and a Focus by Laidlaw et al.

  • Editor's Summary
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• Interferon-driven deletion of antiviral B cells at the onset of chronic infection

  By Benedict Fallet, Kerstin Narr, Yusuf I. Ertuna, Melissa Remy, Rami Sommerstein, Karen Cornille, Mario Kreutzfeldt, Nicolas Page, Gert Zimmer, Florian Geier, Tobias Straub, Hanspeter Pircher, Kevin Larimore, Philip D. Greenberg, Doron Merkler, Daniel D. Pinschewer

  Science Immunology21 Oct 2016 Full AccessRestricted Access

  Interferon-driven inflammation in chronic viral infection blocks generation of sustained B cell responses. See related Research Articles by Moseman et al. and Sammicheli et al. and a Focus by Laidlaw et al.

  • Editor's Summary
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• Inflammatory monocytes hinder antiviral B cell responses

  By Stefano Sammicheli, Mirela Kuka, Pietro Di Lucia, Nereida Jiménez de Oya, Marco De Giovanni, Jessica Fioravanti, Claudia Cristofani, Carmela G. Maganuco, Benedict Fallet, Lucia Ganzer, Laura Sironi, Marta Mainetti, Renato Ostuni, Kevin Larimore, Philip D. Greenberg, Juan Carlos de la Torre, Luca G. Guidotti, Matteo Iannacone

  Science Immunology21 Oct 2016 Full AccessRestricted Access

  LCMV evades B cell responses by recruiting inflammatory monocytes to draining lymph nodes. See related Research Articles by Fallet et al. and Moseman et al. and a Focus by Laidlaw et al.

  • Editor's Summary
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• Group B Streptococcus circumvents neutrophils and neutrophil extracellular traps during amniotic cavity invasion and preterm labor

  By Erica Boldenow, Claire Gendrin, Lisa Ngo, Craig Bierle, Jay Vornhagen, Michelle Coleman, Sean Merillat, Blair Armistead, Christopher Whidbey, Varchita Alishetti, Veronica Santana-Ufret, Jason Ogle, Michael Gough, Sengkeo Srinouanprachanh, James W. MacDonald, Theo K. Bammler, Aasthaa Bansal, H. Denny Liggitt, Lakshmi Rajagopal, Kristina M. Adams Waldorf

  Science Immunology14 Oct 2016 Full AccessRestricted Access

  Group B streptococci overcome neutrophils in placental membranes, inducing fetal injury and preterm labor.

  • Editor's Summary
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• Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome

  By Julien Zuber, Brittany Shonts, Sai-Ping Lau, Aleksandar Obradovic, Jianing Fu, Suxiao Yang, Marion Lambert, Shana Coley, Joshua Weiner, Joseph Thome, Susan DeWolf, Donna L. Farber, Yufeng Shen, Sophie Caillat-Zucman, Govind Bhagat, Adam Griesemer, Mercedes Martinez, Tomoaki Kato, Megan Sykes

  Science Immunology07 Oct 2016 Full AccessRestricted Access

  Clinical transplant outcomes reflect the balance between host-versus-graft and graft-versus-host reactivities.

  • Editor's Summary
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