Contents

Research Articles

• A TSLP-complement axis mediates neutrophil killing of methicillin-resistant Staphylococcus aureus

  By Erin E. West, Rosanne Spolski, Majid Kazemian, Zu Xi Yu, Claudia Kemper, Warren J. Leonard

  Science Immunology18 Nov 2016 Full AccessRestricted Access

  Thymic stromal lymphopoietin increases MRSA killing in a neutrophil- and complement-dependent manner.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes

  By S. Alice Long, Jerill Thorpe, Hannah A. DeBerg, Vivian Gersuk, James A. Eddy, Kristina M. Harris, Mario Ehlers, Kevan C. Herold, Gerald T. Nepom, Peter S. Linsley

  Science Immunology18 Nov 2016 Full AccessRestricted Access

  Features of T cell exhaustion in CD8 T cells are associated with beneficial response to anti-CD3 therapy in T1D.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials

• IL-10 induces a STAT3-dependent autoregulatory loop in T_H2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes

  By Amanda C. Poholek, Dragana Jankovic, Alejandro V. Villarino, Franziska Petermann, Angela Hettinga, Dror S. Shouval, Scott B. Snapper, Susan M. Kaech, Stephen R. Brooks, Golnaz Vahedi, Alan Sher, Yuka Kanno, John J. O’Shea

  Science Immunology11 Nov 2016 Full AccessRestricted Access

  STAT3-mediated Blimp-1 induction in T cells antagonizes STAT5’s role in promoting cell cycle and cell survival genes.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• Adenovirus serotype 5 vaccine vectors trigger IL-27–dependent inhibitory CD4⁺ T cell responses that impair CD8⁺ T cell function

  By Rafael A. Larocca, Nicholas M. Provine, Malika Aid, M. Justin Iampietro, Erica N. Borducchi, Alexander Badamchi-Zadeh, Peter Abbink, David Ng’ang’a, Christine A. Bricault, Eryn Blass, Pablo Penaloza-MacMaster, Kathryn E. Stephenson, Dan H. Barouch

  Science Immunology04 Nov 2016 Full AccessRestricted Access

  Negative immunologic regulatory pathways of vaccine vectors suppress antigen-specific CD8⁺ T cell responses.

  • Editor's Summary
  • Abstract
  • Full Text
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  • Supplementary Materials