Contents
November 2016
Vol 1, Issue 5
Vol 1, Issue 5
Research Articles
- A TSLP-complement axis mediates neutrophil killing of methicillin-resistant Staphylococcus aureus
Thymic stromal lymphopoietin increases MRSA killing in a neutrophil- and complement-dependent manner.
- Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes
Features of T cell exhaustion in CD8 T cells are associated with beneficial response to anti-CD3 therapy in T1D.
- IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes
STAT3-mediated Blimp-1 induction in T cells antagonizes STAT5’s role in promoting cell cycle and cell survival genes.
- Adenovirus serotype 5 vaccine vectors trigger IL-27–dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function
Negative immunologic regulatory pathways of vaccine vectors suppress antigen-specific CD8+ T cell responses.
About The Cover
ONLINE COVER Boosting Viral Vector Vaccines. Adenoviruses (shown) can be used as viral vectors to deliver vaccines, but the immune response to these vectors may be partially exhausted. Larocca et al. now report the mechanism behind this exhaustion. [CREDIT: JAMES CAVALLINI/SCIENCE SOURCE]