Research ArticleVACCINES

Adenovirus serotype 5 vaccine vectors trigger IL-27–dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function

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Science Immunology  04 Nov 2016:
Vol. 1, Issue 5, eaaf7643
DOI: 10.1126/sciimmunol.aaf7643

Article Information

vol. 1 no. 5

PubMed: 
Published By: 
History: 
  • Received March 26, 2016
  • Accepted September 14, 2016
  • .

Author Information

  1. Rafael A. Larocca1,
  2. Nicholas M. Provine1,
  3. Malika Aid1,
  4. M. Justin Iampietro1,
  5. Erica N. Borducchi1,
  6. Alexander Badamchi-Zadeh1,
  7. Peter Abbink1,
  8. David Ng’ang’a1,
  9. Christine A. Bricault1,
  10. Eryn Blass1,
  11. Pablo Penaloza-MacMaster1,2,
  12. Kathryn E. Stephenson1 and
  13. Dan H. Barouch1,3,*
  1. 1Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  2. 2Department of Microbiology and Immunology, Northwestern University, Chicago, IL 60611, USA.
  3. 3Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  1. *Corresponding author. Email: dbarouch{at}bidmc.harvard.edu

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