Research ArticleAUTOIMMUNITY

IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes

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Science Immunology  11 Nov 2016:
Vol. 1, Issue 5, eaaf8612
DOI: 10.1126/sciimmunol.aaf8612

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Regulating Blimp-1 in TH2 cells

The transcription factor Blimp-1 has been reported to limit autoimmunity in T cells. Now, Poholek et al. explore the mechanisms regulating Blimp-1 expression in T helper 2 (TH2) cells. They found that the cytokine interleukin-10 (IL-10) induced Blimp-1 expression in TH2 cells through STAT3. Signal transducer and activator of transcription 3 (STAT3) and Blimp-1 then acted together to boost IL-10 expression in a positive regulatory loop. The induced Blimp-1 then limited cell expansion by inhibiting STAT5 induction of cell cycle and antiapoptotic genes. Thus, by activating Blimp-1, IL-10 may prevent cell expansion, thus restraining autoimmunity.