Contents
December 2016
Vol 1, Issue 6
Vol 1, Issue 6
Research Articles
- The human thymus perivascular space is a functional niche for viral-specific plasma cells
The human thymus perivascular space houses viral-specific plasma cells and memory B cells producing protective antibodies.
- Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment
Transcriptional identity of human dendritic cell subsets is mainly dictated by ontogeny rather than by signals derived from the cells’ final tissue microenvironment.
- Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors
Anti–RSV F antibody repertoire profiling reveals new opportunities for vaccine design and passive therapy.
- The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness
The transcription factor TCF1 determines the degree of CD8+ T cell exhaustion in chronic infection.
- Cross-talk between iNKT cells and monocytes triggers an atheroprotective immune response in SLE patients with asymptomatic plaque
Altered activation of invariant natural killer T cells protects against atherogenesis in systemic lupus erythematosus patients.
- Long-term maintenance of human naïve T cells through in situ homeostasis in lymphoid tissue sites
Human naïve T cells are maintained in lymph nodes for decades and clonally expand in situ after cessation of thymopoiesis.
Review
- Primary immunodeficiencies suggest redundancy within the human immune system
The frequency of innate immune mutations in primary immunodeficiencies suggests redundancy in infection response.
Research Resource
- Characterization of T and B cell repertoire diversity in patients with RAG deficiency
Differences in B and T cell repertoires in patients with RAG deficiency associate with clinical severity.
About The Cover
ONLINE COVER Protecting Against Plaques. Lipids and immune cells both contribute to atherosclerosis (shown). Smith et al. connect these two players, showing that lipid-stimulated iNKT cells can influence plaque development and cardiovascular disease in patients with systemic lupus erythematosus. [CREDIT: BO VEISLAND/SCIENCE SOURCE]